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A novel splicing variant of mouse interleukin (IL)-24 antagonizes IL-24-induced apoptosis

Authors
 Anupama Sahoo  ;  Yun Min Jung  ;  Ho-Keun Kwon  ;  Hwa-Jung Yi  ;  Suho Lee  ;  Sunghoe Chang  ;  Zee-Yong Park  ;  Ki-Chul Hwang  ;  Sin-Hyeog Im 
Citation
 JOURNAL OF BIOLOGICAL CHEMISTRY, Vol.283(43) : 288860-288872, 2008 
Journal Title
 JOURNAL OF BIOLOGICAL CHEMISTRY 
ISSN
 0021-9258 
Issue Date
2008
Abstract
Alternative splicing of mRNA enables functionally diverse protein isoforms to be expressed from a single gene, allowing transcriptome diversification. Interleukin (IL)-24/MDA-7 is a member of the IL-10 gene family, and FISP (IL-4-induced secreted protein), its murine homologue, is selectively expressed and secreted by T helper 2 lymphocytes. A novel splice variant of mouse IL-24/FISP, designated FISP-sp, lacks 29 nucleotides from the 5'-end of exon 4 of FISP. The level of FISP-sp expression is 10% of the level of total primary FISP transcription. Unlike FISP, FISP-sp does not induce growth inhibition and apoptosis. FISP-sp is exclusively localized in endoplasmic reticulum, and its expression is up-regulated by endoplasmic reticulum stress. Our results suggest that the novel splicing variant FISP-sp dimerizes with FISP and blocks its secretion and inhibits FISP-induced apoptosis in vivo.
Files in This Item:
T200895903.pdf Download
DOI
10.1074/jbc.M802510200
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Hwang, Ki Chul(황기철)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111149
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