Cited 21 times in
A novel splicing variant of mouse interleukin (IL)-24 antagonizes IL-24-induced apoptosis
DC Field | Value | Language |
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dc.contributor.author | 황기철 | - |
dc.date.accessioned | 2015-06-11T14:11:53Z | - |
dc.date.available | 2015-06-11T14:11:53Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/111149 | - |
dc.description.abstract | Alternative splicing of mRNA enables functionally diverse protein isoforms to be expressed from a single gene, allowing transcriptome diversification. Interleukin (IL)-24/MDA-7 is a member of the IL-10 gene family, and FISP (IL-4-induced secreted protein), its murine homologue, is selectively expressed and secreted by T helper 2 lymphocytes. A novel splice variant of mouse IL-24/FISP, designated FISP-sp, lacks 29 nucleotides from the 5'-end of exon 4 of FISP. The level of FISP-sp expression is 10% of the level of total primary FISP transcription. Unlike FISP, FISP-sp does not induce growth inhibition and apoptosis. FISP-sp is exclusively localized in endoplasmic reticulum, and its expression is up-regulated by endoplasmic reticulum stress. Our results suggest that the novel splicing variant FISP-sp dimerizes with FISP and blocks its secretion and inhibits FISP-induced apoptosis in vivo. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | A novel splicing variant of mouse interleukin (IL)-24 antagonizes IL-24-induced apoptosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Life Science (의생명과학부) | - |
dc.contributor.googleauthor | Anupama Sahoo | - |
dc.contributor.googleauthor | Yun Min Jung | - |
dc.contributor.googleauthor | Ho-Keun Kwon | - |
dc.contributor.googleauthor | Hwa-Jung Yi | - |
dc.contributor.googleauthor | Suho Lee | - |
dc.contributor.googleauthor | Sunghoe Chang | - |
dc.contributor.googleauthor | Zee-Yong Park | - |
dc.contributor.googleauthor | Ki-Chul Hwang | - |
dc.contributor.googleauthor | Sin-Hyeog Im | - |
dc.identifier.doi | 10.1074/jbc.M802510200 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04456 | - |
dc.relation.journalcode | J01258 | - |
dc.identifier.eissn | 1083-351X | - |
dc.contributor.alternativeName | Hwang, Ki Chul | - |
dc.contributor.affiliatedAuthor | Hwang, Ki Chul | - |
dc.rights.accessRights | not available | - |
dc.citation.volume | 283 | - |
dc.citation.number | 43 | - |
dc.citation.startPage | 288860 | - |
dc.citation.endPage | 288872 | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOLOGICAL CHEMISTRY, Vol.283(43) : 288860-288872, 2008 | - |
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