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A novel splicing variant of mouse interleukin (IL)-24 antagonizes IL-24-induced apoptosis

DC FieldValueLanguage
dc.contributor.author황기철-
dc.date.accessioned2015-06-11T14:11:53Z-
dc.date.available2015-06-11T14:11:53Z-
dc.date.issued2008-
dc.identifier.issn0021-9258-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/111149-
dc.description.abstractAlternative splicing of mRNA enables functionally diverse protein isoforms to be expressed from a single gene, allowing transcriptome diversification. Interleukin (IL)-24/MDA-7 is a member of the IL-10 gene family, and FISP (IL-4-induced secreted protein), its murine homologue, is selectively expressed and secreted by T helper 2 lymphocytes. A novel splice variant of mouse IL-24/FISP, designated FISP-sp, lacks 29 nucleotides from the 5'-end of exon 4 of FISP. The level of FISP-sp expression is 10% of the level of total primary FISP transcription. Unlike FISP, FISP-sp does not induce growth inhibition and apoptosis. FISP-sp is exclusively localized in endoplasmic reticulum, and its expression is up-regulated by endoplasmic reticulum stress. Our results suggest that the novel splicing variant FISP-sp dimerizes with FISP and blocks its secretion and inhibits FISP-induced apoptosis in vivo.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfJOURNAL OF BIOLOGICAL CHEMISTRY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleA novel splicing variant of mouse interleukin (IL)-24 antagonizes IL-24-induced apoptosis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Life Science (의생명과학부)-
dc.contributor.googleauthorAnupama Sahoo-
dc.contributor.googleauthorYun Min Jung-
dc.contributor.googleauthorHo-Keun Kwon-
dc.contributor.googleauthorHwa-Jung Yi-
dc.contributor.googleauthorSuho Lee-
dc.contributor.googleauthorSunghoe Chang-
dc.contributor.googleauthorZee-Yong Park-
dc.contributor.googleauthorKi-Chul Hwang-
dc.contributor.googleauthorSin-Hyeog Im-
dc.identifier.doi10.1074/jbc.M802510200-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04456-
dc.relation.journalcodeJ01258-
dc.identifier.eissn1083-351X-
dc.contributor.alternativeNameHwang, Ki Chul-
dc.contributor.affiliatedAuthorHwang, Ki Chul-
dc.rights.accessRightsnot available-
dc.citation.volume283-
dc.citation.number43-
dc.citation.startPage288860-
dc.citation.endPage288872-
dc.identifier.bibliographicCitationJOURNAL OF BIOLOGICAL CHEMISTRY, Vol.283(43) : 288860-288872, 2008-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers

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