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Paradoxically accelerated fatal brain herniation following thrombolytic therapy in acute ischemic stroke

Authors
 Sang Won Han  ;  Seo Hyun Kim  ;  Ha Young Shin  ;  Hye Yeon Choi  ;  Chan Hee Park  ;  Jin Kwon Kim  ;  Ji Hoe Heo 
Citation
 Neurocritical Care, Vol.5(1) : 35-38, 2006 
Journal Title
 Neurocritical Care 
ISSN
 1541-6933 
Issue Date
2006
Abstract
INTRODUCTION: The use of plasminogen activators (PAs) in acute stroke patients has dual effects. PAs are beneficial by dissolving thrombi occluding an artery, but may be harmful by their proteolytic and excitotoxic actions. METHODS AND RESULTS: We report two patients with a fatal brain herniation who rapidly deteriorated despite the successful recanalization and the sustained arterial patency or blood flow. Imaging studies taken after the thrombolytic treatment suggested early occurrence of cellular damage and profound breakdown of the blood-brain barrier. CONCLUSION: Fatal brain edema occurred after persistent reperfusion by the thrombolytic therapy. Paradoxical thrombolytic-induced injury, which has been suggested in experimental studies, might play a role.
Full Text
http://link.springer.com/article/10.1385%2FNCC%3A5%3A1%3A35
DOI
10.1385/NCC:5:1:35
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Heo, Ji Hoe(허지회) ORCID logo https://orcid.org/0000-0001-9898-3321
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111066
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