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Paradoxically accelerated fatal brain herniation following thrombolytic therapy in acute ischemic stroke

DC FieldValueLanguage
dc.contributor.author허지회-
dc.date.accessioned2015-06-10T13:07:55Z-
dc.date.available2015-06-10T13:07:55Z-
dc.date.issued2006-
dc.identifier.issn1541-6933-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/111066-
dc.description.abstractINTRODUCTION: The use of plasminogen activators (PAs) in acute stroke patients has dual effects. PAs are beneficial by dissolving thrombi occluding an artery, but may be harmful by their proteolytic and excitotoxic actions. METHODS AND RESULTS: We report two patients with a fatal brain herniation who rapidly deteriorated despite the successful recanalization and the sustained arterial patency or blood flow. Imaging studies taken after the thrombolytic treatment suggested early occurrence of cellular damage and profound breakdown of the blood-brain barrier. CONCLUSION: Fatal brain edema occurred after persistent reperfusion by the thrombolytic therapy. Paradoxical thrombolytic-induced injury, which has been suggested in experimental studies, might play a role.-
dc.description.statementOfResponsibilityopen-
dc.format.extent35~38-
dc.relation.isPartOfNeurocritical Care-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHBrain/blood supply*-
dc.subject.MESHBrain/diagnostic imaging*-
dc.subject.MESHBrain Ischemia/diagnosis*-
dc.subject.MESHBrain Ischemia/drug therapy*-
dc.subject.MESHCarotid Stenosis/drug therapy-
dc.subject.MESHCerebral Angiography-
dc.subject.MESHEncephalocele/diagnosis-
dc.subject.MESHEncephalocele/etiology*-
dc.subject.MESHFatal Outcome-
dc.subject.MESHFemale-
dc.subject.MESHFibrinolytic Agents/administration & dosage-
dc.subject.MESHFibrinolytic Agents/therapeutic use*-
dc.subject.MESHHumans-
dc.subject.MESHInjections, Intra-Arterial-
dc.subject.MESHMiddle Cerebral Artery-
dc.subject.MESHTime Factors-
dc.subject.MESHTomography, X-Ray Computed-
dc.subject.MESHUrokinase-Type Plasminogen Activator/administration & dosage-
dc.subject.MESHUrokinase-Type Plasminogen Activator/therapeutic use*-
dc.titleParadoxically accelerated fatal brain herniation following thrombolytic therapy in acute ischemic stroke-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학)-
dc.contributor.googleauthorSang Won Han-
dc.contributor.googleauthorSeo Hyun Kim-
dc.contributor.googleauthorHa Young Shin-
dc.contributor.googleauthorHye Yeon Choi-
dc.contributor.googleauthorChan Hee Park-
dc.contributor.googleauthorJin Kwon Kim-
dc.contributor.googleauthorJi Hoe Heo-
dc.identifier.doi10.1385/NCC:5:1:35-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04369-
dc.relation.journalcodeJ02327-
dc.identifier.pmid16960292-
dc.identifier.urlhttp://link.springer.com/article/10.1385%2FNCC%3A5%3A1%3A35-
dc.subject.keywordBrain edema-
dc.subject.keywordcerebral infarction-
dc.subject.keywordplasminogen activators-
dc.contributor.alternativeNameHeo, Ji Hoe-
dc.contributor.affiliatedAuthorHeo, Ji Hoe-
dc.rights.accessRightsnot free-
dc.citation.volume5-
dc.citation.number1-
dc.citation.startPage35-
dc.citation.endPage38-
dc.identifier.bibliographicCitationNeurocritical Care, Vol.5(1) : 35-38, 2006-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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