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Both integrated and differential regulation of components of the IL-2/IL-2 receptor system

Authors
 Hyoung Pyo Kim  ;  Jean Imbert  ;  Warren J. Leonard 
Citation
 CYTOKINE & GROWTH FACTOR REVIEWS, Vol.17(5) : 349-366, 2006 
Journal Title
CYTOKINE & GROWTH FACTOR REVIEWS
ISSN
 1359-6101 
Issue Date
2006
MeSH
Animals ; Cyclic AMP Response Element Modulator/physiology ; Cyclic AMP Response Element-Binding Protein/physiology ; Gene Expression Regulation ; Humans ; Interleukin-2/genetics* ; Interleukin-2 Receptor alpha Subunit/genetics ; Interleukin-2 Receptor beta Subunit/genetics ; Mice ; NF-kappa B/physiology ; NFATC Transcription Factors/physiology ; Phenotype ; RNA Processing, Post-Transcriptional/physiology ; Receptors, Interleukin-2/genetics* ; STAT5 Transcription Factor/physiology ; Transcription Factor AP-1/physiology
Keywords
IL-2 ; IL-2 receptor ; Transcription ; γc ; XSCID
Abstract
Interleukin-2 was discovered in 1976 as a T-cell growth factor. It was the first type I cytokine cloned and the first for which a receptor component was cloned. Its importance includes its multiple actions, therapeutic potential, and lessons for receptor biology, with three components differentially combining to form high, intermediate, and low-affinity receptors. IL-2Rα and IL-2Rβ, respectively, are markers for double-negative thymocytes and regulatory T-cells versus memory cells. γc, which is shared by six cytokines, is mutated in patients with X-linked severe-combined immunodeficiency. We now cover an under-reviewed area—the regulation of genes encoding IL-2 and IL-2R components, with an effort to integrate/explain this knowledge.
Full Text
http://www.sciencedirect.com/science/article/pii/S1359610106000487
DOI
10.1016/j.cytogfr.2006.07.003
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Environmental Medical Biology (환경의생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyoung Pyo(김형표) ORCID logo https://orcid.org/0000-0003-1441-8822
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111059
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