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Both integrated and differential regulation of components of the IL-2/IL-2 receptor system

DC Field Value Language
dc.contributor.author김형표-
dc.date.accessioned2015-06-10T13:07:42Z-
dc.date.available2015-06-10T13:07:42Z-
dc.date.issued2006-
dc.identifier.issn1359-6101-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/111059-
dc.description.abstractInterleukin-2 was discovered in 1976 as a T-cell growth factor. It was the first type I cytokine cloned and the first for which a receptor component was cloned. Its importance includes its multiple actions, therapeutic potential, and lessons for receptor biology, with three components differentially combining to form high, intermediate, and low-affinity receptors. IL-2Rα and IL-2Rβ, respectively, are markers for double-negative thymocytes and regulatory T-cells versus memory cells. γc, which is shared by six cytokines, is mutated in patients with X-linked severe-combined immunodeficiency. We now cover an under-reviewed area—the regulation of genes encoding IL-2 and IL-2R components, with an effort to integrate/explain this knowledge.-
dc.description.statementOfResponsibilityopen-
dc.format.extent349~366-
dc.relation.isPartOfCYTOKINE & GROWTH FACTOR REVIEWS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCyclic AMP Response Element Modulator/physiology-
dc.subject.MESHCyclic AMP Response Element-Binding Protein/physiology-
dc.subject.MESHGene Expression Regulation-
dc.subject.MESHHumans-
dc.subject.MESHInterleukin-2/genetics*-
dc.subject.MESHInterleukin-2 Receptor alpha Subunit/genetics-
dc.subject.MESHInterleukin-2 Receptor beta Subunit/genetics-
dc.subject.MESHMice-
dc.subject.MESHNF-kappa B/physiology-
dc.subject.MESHNFATC Transcription Factors/physiology-
dc.subject.MESHPhenotype-
dc.subject.MESHRNA Processing, Post-Transcriptional/physiology-
dc.subject.MESHReceptors, Interleukin-2/genetics*-
dc.subject.MESHSTAT5 Transcription Factor/physiology-
dc.subject.MESHTranscription Factor AP-1/physiology-
dc.titleBoth integrated and differential regulation of components of the IL-2/IL-2 receptor system-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Environmental Medical Biology (환경의생물학)-
dc.contributor.googleauthorHyoung Pyo Kim-
dc.contributor.googleauthorJean Imbert-
dc.contributor.googleauthorWarren J. Leonard-
dc.identifier.doi10.1016/j.cytogfr.2006.07.003-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01163-
dc.relation.journalcodeJ00692-
dc.identifier.eissn1879-0305-
dc.identifier.pmid16911870-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S1359610106000487-
dc.subject.keywordIL-2-
dc.subject.keywordIL-2 receptor-
dc.subject.keywordTranscription-
dc.subject.keywordγc-
dc.subject.keywordXSCID-
dc.contributor.alternativeNameKim, Hyoung Pyo-
dc.contributor.affiliatedAuthorKim, Hyoung Pyo-
dc.rights.accessRightsnot free-
dc.citation.volume17-
dc.citation.number5-
dc.citation.startPage349-
dc.citation.endPage366-
dc.identifier.bibliographicCitationCYTOKINE & GROWTH FACTOR REVIEWS, Vol.17(5) : 349-366, 2006-
dc.identifier.rimsid51952-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Environmental Medical Biology (환경의생물학교실) > 1. Journal Papers

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