384 606

Cited 126 times in

A Femtosecond Laser Creates a Stronger Flap than a Mechanical Microkeratome

Authors
 Jae Yong Kim  ;  Myoung Joon Kim  ;  Tae-im Kim  ;  Hyun-jeung Choi  ;  Jhang Ho Pak  ;  Hungwon Tchah 
Citation
 INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol.47(2) : 599-604, 2006 
Journal Title
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
ISSN
 0146-0404 
Issue Date
2006
MeSH
Animals ; Apoptosis ; Cell Adhesion ; Corneal Stroma/physiopathology* ; Corneal Stroma/surgery* ; In Situ Nick-End Labeling ; Keratitis/etiology ; Keratitis/physiopathology ; Keratomileusis, Laser In Situ/instrumentation ; Keratomileusis, Laser In Situ/methods* ; Lasers ; Models, Animal ; Postoperative Complications/physiopathology ; Rabbits ; Surgical Flaps* ; Tensile Strength/physiology ; Wound Healing/physiology*
Abstract
PURPOSE: To compare corneal flaps made with a femtosecond (FS) laser with those made with a mechanical microkeratome (MM) in rabbits, measuring early postoperative inflammation and apoptosis and late postoperative adhesion strength.
METHODS: Study 1 involved four treatment groups: one with flaps made only with the FS laser (FS group), one with flaps made with the FS laser followed by excimer laser ablation (FS+LASIK), one with flaps made with the MM, and one with flaps made with the MM followed by excimer laser ablation (MM+LASIK). The eyes were analyzed by histology and TUNEL staining for apoptosis at 4 and 24 hours. Study 2 involved two reference groups: an FS group and an MM group. Adhesion strength was measured with a tension meter 1 and 3 months later.
RESULTS: Study 1: Inflammatory cell infiltration in the central cornea was significantly greater in the FS group than in the MM group at 4 and 24 hours (P < 0.05) and was significantly greater in the FS+LASIK group than in the MM+LASIK group at 24 hours (P < 0.05). Infiltration at the peripheral interface was significantly greater in the FS group than in the MM group and was significantly greater in the FS+LASIK group than in the MM+LASIK group at 24 hours (P < 0.05). Study 2: At 1 and 3 months, 126.7 and 191.3 grams of force (gf) were needed to detach the flaps in the FS group, compared with 65 and 127.5 gf in the MM group, respectively. The grams of force needed was significantly higher in the FS group than in the MM group at 3 months (P < 0.05).
CONCLUSIONS: The FS laser produces greater corneal stromal inflammation than the MM early postoperatively without any increase in apoptosis and stronger flap adhesion late postoperatively. Therefore, it may require stronger anti-inflammatory drugs to be administered.
Files in This Item:
T200604781.pdf Download
DOI
10.1167/iovs.05-0458
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Tae-Im(김태임) ORCID logo https://orcid.org/0000-0001-6414-3842
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111049
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links