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In vitro anticandidal activity of xanthorrhizol isolated from Curcuma xanthorrhiza Roxb

 Yaya Rukayadi  ;  Dongeun Yong  ;  Jae-Kwan Hwang 
 Journal of Antimicrobial Chemotherapy, Vol.57(6) : 1231-1234, 2006 
Journal Title
 Journal of Antimicrobial Chemotherapy 
Issue Date
OBJECTIVES: Xanthorrhizol, isolated from the methanol extract of Curcuma xanthorrhiza Roxb., was investigated for its anticandidal activity using six Candida species. METHODS: The in vitro susceptibility tests for xanthorrhizol were carried out in terms of MIC and minimal fungicidal concentration (MFC) using the NCCLS M27-A2 broth microdilution method. Time-kill curves were determined to assess the correlation between MIC and fungicidal activity of xanthorrhizol at concentrations ranging from 0 MIC to 4x MIC. RESULTS: All Candida species showed susceptibility to xanthorrhizol in the MIC range 1.0-15.0 mg/L for Candida albicans, 1.0-10 mg/L for Candida glabrata, 2.0-8.0 mg/L for Candida guilliermondii, 2.5-7.5 mg/L for Candida krusei, 2.5-25 mg/L for Candida parapsilosis and 2.0-8.0 mg/L for Candida tropicalis. Time-kill curves demonstrated that xanthorrhizol was able to kill the Candida strains with MFCs of 20 mg/mL, 15 mg/mL, 12.5 mg/mL, 10 mg/L, 30 mg/mL and 10 mg/L for C. albicans, C. glabrata, C. guilliermondii, C. krusei, C. parapsilosis and C. tropicalis, respectively. CONCLUSIONS: The potent anticandidal activity of xanthorrhizol may support the use of C. xanthorriza for the treatment of candidiasis.
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Yonsei Authors
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
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