Cited 70 times in
In vitro anticandidal activity of xanthorrhizol isolated from Curcuma xanthorrhiza Roxb
DC Field | Value | Language |
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dc.contributor.author | 용동은 | - |
dc.date.accessioned | 2015-06-10T13:02:46Z | - |
dc.date.available | 2015-06-10T13:02:46Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0305-7453 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/110908 | - |
dc.description.abstract | OBJECTIVES: Xanthorrhizol, isolated from the methanol extract of Curcuma xanthorrhiza Roxb., was investigated for its anticandidal activity using six Candida species. METHODS: The in vitro susceptibility tests for xanthorrhizol were carried out in terms of MIC and minimal fungicidal concentration (MFC) using the NCCLS M27-A2 broth microdilution method. Time-kill curves were determined to assess the correlation between MIC and fungicidal activity of xanthorrhizol at concentrations ranging from 0 MIC to 4x MIC. RESULTS: All Candida species showed susceptibility to xanthorrhizol in the MIC range 1.0-15.0 mg/L for Candida albicans, 1.0-10 mg/L for Candida glabrata, 2.0-8.0 mg/L for Candida guilliermondii, 2.5-7.5 mg/L for Candida krusei, 2.5-25 mg/L for Candida parapsilosis and 2.0-8.0 mg/L for Candida tropicalis. Time-kill curves demonstrated that xanthorrhizol was able to kill the Candida strains with MFCs of 20 mg/mL, 15 mg/mL, 12.5 mg/mL, 10 mg/L, 30 mg/mL and 10 mg/L for C. albicans, C. glabrata, C. guilliermondii, C. krusei, C. parapsilosis and C. tropicalis, respectively. CONCLUSIONS: The potent anticandidal activity of xanthorrhizol may support the use of C. xanthorriza for the treatment of candidiasis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1231~1234 | - |
dc.relation.isPartOf | JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Antifungal Agents/isolation & purification | - |
dc.subject.MESH | Antifungal Agents/pharmacology* | - |
dc.subject.MESH | Candida/drug effects* | - |
dc.subject.MESH | Colony Count, Microbial | - |
dc.subject.MESH | Curcuma/chemistry* | - |
dc.subject.MESH | Microbial Sensitivity Tests | - |
dc.subject.MESH | Phenols/isolation & purification | - |
dc.subject.MESH | Phenols/pharmacology* | - |
dc.subject.MESH | Plant Extracts/pharmacology | - |
dc.title | In vitro anticandidal activity of xanthorrhizol isolated from Curcuma xanthorrhiza Roxb | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | Yaya Rukayadi | - |
dc.contributor.googleauthor | Dongeun Yong | - |
dc.contributor.googleauthor | Jae-Kwan Hwang | - |
dc.identifier.doi | 10.1093/jac/dkl132 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02423 | - |
dc.relation.journalcode | J01237 | - |
dc.identifier.eissn | 1460-2091 | - |
dc.identifier.pmid | 16617064 | - |
dc.subject.keyword | C. xanthorriza | - |
dc.subject.keyword | MIC | - |
dc.subject.keyword | MFC | - |
dc.subject.keyword | antifungals | - |
dc.contributor.alternativeName | Yong, Dong Eun | - |
dc.contributor.affiliatedAuthor | Yong, Dong Eun | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 57 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1231 | - |
dc.citation.endPage | 1234 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, Vol.57(6) : 1231-1234, 2006 | - |
dc.identifier.rimsid | 55611 | - |
dc.type.rims | ART | - |
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