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HBeAg 음성 만성 B형간염바이러스 감염의 자연경과: 코호트 연구

Other Titles
 Natural History of HBeAg Negative Chronic Hepatitis B Virus Infection; A Cohort Study 
 문창모  ;  김도영  ;  송기준  ;  김자경  ;  이현웅  ;  이중민  ;  윤기태  ;  백용한  ;  김동기  ;  한광협  ;  전재윤  ;  문영명  ;  안상훈 
 Korean Journal of Hepatology (대한간학회지), Vol.12(2) : 163-172, 2006 
Journal Title
Korean Journal of Hepatology(대한간학회지)
Issue Date
Adult ; Carrier State/immunology ; Female ; Hepatitis B e Antigens/blood* ; Hepatitis B, Chronic/immunology* ; Hepatitis B, Chronic/virology ; Humans ; Male ; Middle Aged
Hepatitis B virus ; Hepatitis B ; chronic ; Hepatitis B e antigens ; Carrier state ; Prognosis
Background/Aims: The long-term virologic and biochemical changes in patients with HBeAg negative HBV infection, especially in Asia, remain unclear. To address this issue, we conducted a 3 year- retrospective, cohort study.
Methods: A total of 157 patients with HBeAg negative HBV infection who were monitored without treatment were reviewed between January 1999 and March 2004. Those patients were followed up every 3 months with liver function tests and serologic tests. All patients were stratified into 3 groups; inactive carrier (IC), viremic carrier (VC) and chronic hepatitis (CH). Serum HBV DNA was measured by a hybridization assay (sensitivity: 1.4×105 genomes/mL, Digene Diagnostics, Silver Spring, USA).
Results: The median age of enrolled patients was 42.7 years (M:F=2.3:1). By single time-point observations, the 3 year-cohort prevalence of HBeAg negative CH varied from 12.7 to 35.8% (median 20.7%) HBeAg negative CH was accumulated over time (P=0.002) and transition rates among three groups after 3 years of follow-up are as follows: IC to CH, 6.0%; IC to VC, 4.1%; VC to CH, 23.2%. VC seems to be a disease state in the middle of transition from IC to CH.
Conclusions: We demonstrated the dynamic changing patterns of HBeAg negative CH with time, of which the change from IC or VC to CH was dominant
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Ki(김동기)
Paik, Yong Han(백용한)
Song, Ki Jun(송기준) ORCID logo https://orcid.org/0000-0003-2505-4112
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Chon, Chae Yoon(전재윤)
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
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