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Comparison of Low-Fat Meal and High-Fat Meal on Postprandial Lipemic Response in Non-Obese Men according to the −1131T>C Polymorphism of the Apolipoprotein A5 (APOA5) Gene (Randomized Cross-Over Design)

Authors
 Ji Young Kim  ;  Oh Yoen Kim  ;  Soo Jeong Koh  ;  Yangsoo Jang  ;  Sung-Seob Yun  ;  Jose M. Ordovas  ;  Jong Ho Lee 
Citation
 JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, Vol.25(4) : 340-347, 2006 
Journal Title
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
ISSN
 0731-5724 
Issue Date
2006
MeSH
Adult ; Apolipoprotein A-V ; Apolipoproteins A/blood ; Apolipoproteins A/genetics* ; Blood Glucose/analysis ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/genetics ; Chylomicrons/blood ; Cross-Over Studies ; Dietary Fats/administration & dosage* ; Dose-Response Relationship, Drug ; Fatty Acids, Nonesterified/blood* ; Gene Frequency ; Genotype ; Humans ; Hypertriglyceridemia/blood ; Hypertriglyceridemia/genetics* ; Insulin/blood ; Lipid Metabolism/genetics ; Lipid Metabolism/physiology ; Male ; Polymorphism, Genetic* ; Postprandial Period ; Risk Factors ; Triglycerides/blood* ; Triglycerides/genetics
Keywords
APOA5 ; C carrier ; high fat meal ; postprandial lipemic response
Abstract
Objective: The purpose of this study was to compare low-fat (LF) meal and high-fat (HF) meal on the postprandial lipemic responses according to the −1131T>C polymorphism of the APOA5 gene in a population usually consuming a LF diet and having a high frequency of the variant allele at the APOA5 −1131T>C SNP.

Methods: This study was conducted using a cross-over design and 49 non-obese healthy men (42.8 ± 0.7 yrs, 23.9 ± 0.25 kg/m2) participated in the meal tolerance test. They were randomly assigned to consume one of two types of experimental enteral formulae (LF vs HF) with a seven-day interval. Blood samples were collected at 0, 2, 3, 4 and 6h after ingestion and analyzed for total and chylomicron TG, glucose, insulin and free fatty acid.

Results: No differences were found in anthropometic parameter, calorie and macronutrient intakes and total energy expenditure between TT (n = 23) and TC + CC (n = 26) men. Fasting total TG were higher in TC + CC men than TT men, but fasting chylomicron TG were not significantly different between TT men and C carriers, TT subjects had no significant differences in postprandial responses of total TG and chylomicron TG and postprandial mean changes of chylomicron TG between LF and HF meal. On the other hand, C carriers had delayed peak time of total TG compared to TT subject and higher postprandial response and mean changes of chylomicron TG at HF meal compared to LF meal.

Conclusion: The capacity to clear chylomicron-TG or hydrolyze TG might become a rate-limiting factor on HF diet in TC + CC men resulting in higher postprandial triglyceridemia. Therefore, HF diet for C carriers of the APOA5 gene may be one of important CVD risk factors.
Full Text
http://www.tandfonline.com/doi/abs/10.1080/07315724.2006.10719544#.U6OdyKizIyp
DOI
10.1080/07315724.2006.10719544
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/110789
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