Cited 33 times in
Comparison of Low-Fat Meal and High-Fat Meal on Postprandial Lipemic Response in Non-Obese Men according to the −1131T>C Polymorphism of the Apolipoprotein A5 (APOA5) Gene (Randomized Cross-Over Design)
DC Field | Value | Language |
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dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2015-06-10T12:58:42Z | - |
dc.date.available | 2015-06-10T12:58:42Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0731-5724 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/110789 | - |
dc.description.abstract | Objective: The purpose of this study was to compare low-fat (LF) meal and high-fat (HF) meal on the postprandial lipemic responses according to the −1131T>C polymorphism of the APOA5 gene in a population usually consuming a LF diet and having a high frequency of the variant allele at the APOA5 −1131T>C SNP. Methods: This study was conducted using a cross-over design and 49 non-obese healthy men (42.8 ± 0.7 yrs, 23.9 ± 0.25 kg/m2) participated in the meal tolerance test. They were randomly assigned to consume one of two types of experimental enteral formulae (LF vs HF) with a seven-day interval. Blood samples were collected at 0, 2, 3, 4 and 6h after ingestion and analyzed for total and chylomicron TG, glucose, insulin and free fatty acid. Results: No differences were found in anthropometic parameter, calorie and macronutrient intakes and total energy expenditure between TT (n = 23) and TC + CC (n = 26) men. Fasting total TG were higher in TC + CC men than TT men, but fasting chylomicron TG were not significantly different between TT men and C carriers, TT subjects had no significant differences in postprandial responses of total TG and chylomicron TG and postprandial mean changes of chylomicron TG between LF and HF meal. On the other hand, C carriers had delayed peak time of total TG compared to TT subject and higher postprandial response and mean changes of chylomicron TG at HF meal compared to LF meal. Conclusion: The capacity to clear chylomicron-TG or hydrolyze TG might become a rate-limiting factor on HF diet in TC + CC men resulting in higher postprandial triglyceridemia. Therefore, HF diet for C carriers of the APOA5 gene may be one of important CVD risk factors. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 340~347 | - |
dc.relation.isPartOf | JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Apolipoprotein A-V | - |
dc.subject.MESH | Apolipoproteins A/blood | - |
dc.subject.MESH | Apolipoproteins A/genetics* | - |
dc.subject.MESH | Blood Glucose/analysis | - |
dc.subject.MESH | Cardiovascular Diseases/blood | - |
dc.subject.MESH | Cardiovascular Diseases/genetics | - |
dc.subject.MESH | Chylomicrons/blood | - |
dc.subject.MESH | Cross-Over Studies | - |
dc.subject.MESH | Dietary Fats/administration & dosage* | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Fatty Acids, Nonesterified/blood* | - |
dc.subject.MESH | Gene Frequency | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypertriglyceridemia/blood | - |
dc.subject.MESH | Hypertriglyceridemia/genetics* | - |
dc.subject.MESH | Insulin/blood | - |
dc.subject.MESH | Lipid Metabolism/genetics | - |
dc.subject.MESH | Lipid Metabolism/physiology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Polymorphism, Genetic* | - |
dc.subject.MESH | Postprandial Period | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Triglycerides/blood* | - |
dc.subject.MESH | Triglycerides/genetics | - |
dc.title | Comparison of Low-Fat Meal and High-Fat Meal on Postprandial Lipemic Response in Non-Obese Men according to the −1131T>C Polymorphism of the Apolipoprotein A5 (APOA5) Gene (Randomized Cross-Over Design) | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Ji Young Kim | - |
dc.contributor.googleauthor | Oh Yoen Kim | - |
dc.contributor.googleauthor | Soo Jeong Koh | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Sung-Seob Yun | - |
dc.contributor.googleauthor | Jose M. Ordovas | - |
dc.contributor.googleauthor | Jong Ho Lee | - |
dc.identifier.doi | 10.1080/07315724.2006.10719544 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03448 | - |
dc.relation.journalcode | J01771 | - |
dc.identifier.eissn | 1541-1087 | - |
dc.identifier.pmid | 16943456 | - |
dc.identifier.url | http://www.tandfonline.com/doi/abs/10.1080/07315724.2006.10719544#.U6OdyKizIyp | - |
dc.subject.keyword | APOA5 | - |
dc.subject.keyword | C carrier | - |
dc.subject.keyword | high fat meal | - |
dc.subject.keyword | postprandial lipemic response | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 25 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 340 | - |
dc.citation.endPage | 347 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, Vol.25(4) : 340-347, 2006 | - |
dc.identifier.rimsid | 54436 | - |
dc.type.rims | ART | - |
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