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Lack of association between polymorphisms of the dopamine receptor D4 and dopamine transporter genes and personality traits in a Korean population

Authors
 Se Joo Kim  ;  Young Shin Kim  ;  Chan-hyung Kim  ;  Hong Shick Lee 
Citation
 YONSEI MEDICAL JOURNAL, Vol.47(6) : 787-792, 2006 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2006
MeSH
Adult ; Dopamine Plasma Membrane Transport Proteins/genetics* ; Female ; Humans ; Korea ; Male ; Personality/genetics* ; Polymorphism, Genetic* ; Receptors, Dopamine D4/genetics* ; Temperament
Keywords
Dopamine receptor D4 ; dopamine transporter gene ; polymorphism ; personality traits ; temperament and character inventory ; Korean
Abstract
Human personality traits have a considerable genetic component. Cloninger et al. were the first to postulate that certain personality traits, such as novelty seeking, are related to the dopamine neurotransmitter system. In this study, we investigated the associations between dopamine receptor D4 (DRD4) exon III and dopamine transporter (DAT1) polymorphisms and personality traits. The DRD4 and DAT1 gene polymorphisms were genotyped in 214 healthy Korean subjects, whose personality traits were assessed with the Temperament and Character Inventory (TCI). There were no significant differences between scores of TCI temperament dimensions (novelty seeking, harm avoidance, reward dependence, and persistence) and DRD4 gene polymorphism. The DAT1 gene polymorphisms also showed no significant association with any of the temperament subscales of the TCI. These data suggest that DRD4 and DAT1 gene polymorphism may not associated with personality traits in a Korean population.
Files in This Item:
T200601658.pdf Download
DOI
10.3349/ymj.2006.47.6.787
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Joo(김세주) ORCID logo https://orcid.org/0000-0002-5438-8210
Kim, Chan Hyung(김찬형)
Lee, Hong Shick(이홍식)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/110673
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