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노인에서 ApoE 유전자형이 영양 위험도와 인지기능에 미치는 영향

Other Titles
 Effect of ApoE Genotype on the Relationship between Nutritional Risk and Cognition in the Elderly 
 홍창형  ;  정해관  ;  김은아  ;  이강수  ;  김경란  ;  차경렬  ;  최지혜  ;  오병훈 
 Journal of the Korean Geriatrics Society (노인병), Vol.10(3) : 177-185, 2006 
Journal Title
 Journal of the Korean Geriatrics Society (노인병) 
Issue Date
nutrition ; NSI checklist ; K-MMSE ; Elderly ; apoE genotyping
Background: The purpose of this study is to find out the effect of ApoE genotype on the relationship between nutritional risk and cognition of the elderly in a community. Methods: A total of 996 subjects (343 men and 653 women) aged 60∼91 years were analyzed from preliminary data of GDEMCIS (Gwangju Dementia and MCI Study). The study questionnaire consisted of demographic characteristics, current and past illness history, drug history, K-SGDS (Korean version of Short Form Geriatric Depression Scale), K-MMSE (Korean version-Mini Mental State Examina- tion), and NSI (Nutritional Screening Initiative) checklist. We also examined blood pressure, fasting serum glucose, lipid profile, body mass index, and ApoE genotyping. Results: 649 subjects (65.2%) were on good nutritional state (NSI score 2) and 347 subjects (34.8%) were on moderate or high nutritional risk (NSI score 3). On multiple logistic regression analysis, moderate or high nutritional risk was associated with an increa- sed risk for cognitive impairment (K-MMSE score 17) after adjustment with age, sex, K-GDS and educational level in the absence of ApoE 4 allele (OR 1.78, 95% CI 1.15-2.77). Conclusion: These results suggest that nutritional risk may be associated with cognitive function in the elderly only in the absence of ApoE 4 allele.
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1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Oh, Byong Hoon(오병훈)
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