노인에서 ApoE 유전자형이 영양 위험도와 인지기능에 미치는 영향

Abstract

Background: The purpose of this study is to find out the effect of ApoE genotype on the relationship between nutritional risk and cognition of the elderly in a community.

Methods: A total of 996 subjects (343 men and 653 women) aged 60∼91 years were analyzed from preliminary data of GDEMCIS (Gwangju Dementia and MCI Study). The study questionnaire consisted of demographic characteristics, current and past illness history, drug history, K-SGDS (Korean version of Short Form Geriatric Depression Scale), K-MMSE (Korean version-Mini Mental State Examina- tion), and NSI (Nutritional Screening Initiative) checklist. We also examined blood pressure, fasting serum glucose, lipid profile, body mass index, and ApoE genotyping.

Results: 649 subjects (65.2%) were on good nutritional state (NSI score 2) and 347 subjects (34.8%) were on moderate or high nutritional risk (NSI score 3). On multiple logistic regression analysis, moderate or high nutritional risk was associated with an increa- sed risk for cognitive impairment (K-MMSE score 17) after adjustment with age, sex, K-GDS and educational level in the absence of ApoE 4 allele (OR 1.78, 95% CI 1.15-2.77).

Conclusion: These results suggest that nutritional risk may be associated with cognitive function in the elderly only in the absence of ApoE 4 allele.