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파킨슨병에 대한 시상하핵 심부뇌자극술

Other Titles
 Subthalamic Deep Brain Stimulation for Parkinson’s Disease 
Authors
 류철형  ;  장진우  ;  이명식 
Citation
 Journal of the Korean Neurological Association, Vol.24(3) : 191-203, 2006 
Journal Title
Journal of the Korean Neurological Association
ISSN
 1225-7044 
Issue Date
2006
Keywords
Parkinson Disease ; Deep brain stimulation ; Subthalamic nucleus
Abstract
The recent progress in the basic knowledge of basal ganglia pathways and advances in the techniques of the neuroimaging studies enabled subthalamic deep brain stimulation (STN DBS). In Korea, more than three hundreds and fifty patients with PD have been treated with STN DBS since the first trial at March 2000. STN DBS effectively improves all parkinsonian deficits occurring especially during levodopa ‘off’ period and decreases the daily ‘off’ time. The daily requirement of levodopa dosage can be reduced to about half of the preoperative one. The favorable responses to the STN DBS can be maintained even after five years. However, parkinsonian deficits during levodopa ‘on’ period can not be controlled as effectively as those during the levodopa ‘off’ period. The axial symptoms including gait disturbance and postural instability during the levodopa ‘on’ period cannot be improved or even are worsen by STN DBS. Patients aged over 70 frequently show less remarkable improvement of parkinsonian deficits than the younger ones. Therefore, selection of appropriate candidate for STN DBS is the most important factor deciding the outcome of the STN DBS.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Myung Sik(이명식) ORCID logo https://orcid.org/0000-0002-8413-1854
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/110221
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