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Effects of sinusoidal electromagnetic field on structure and function of different kinds of cell lines

Authors
 Ah Ram Sul  ;  Si-nae Park  ;  Hwal Suh 
Citation
 YONSEI MEDICAL JOURNAL, Vol.47(6) : 852-861, 2006 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2006
MeSH
Actin Cytoskeleton/radiation effects ; Cell Cycle/radiation effects ; Cell Differentiation/radiation effects ; Cell Line ; Cell Physiological Phenomena/radiation effects* ; Cell Proliferation/radiation effects ; Electromagnetic Fields* ; Gap Junctions/metabolism ; Gap Junctions/radiation effects ; Humans ; Signal Transduction
Keywords
Electromagnetic field ; fetal osteoblast ; aortic vascular smooth muscle cell ; B lymphoblast ; cortical neuronal cell ; proliferation
Abstract
This study investigated that whether a 2 mT, 60 Hz, sinusoidal electromagnetic field (EMF) alters the structure and function of cells. This research compared the effects of EMF on four kinds of cell lines: hFOB 1.19 (fetal osteoblast), T/G HA-VSMC (aortic vascular smooth muscle cell), RPMI 7666 (B lymphoblast), and HCN-2 (cortical neuronal cell). Over 14 days, cells were exposed to EMF for 1, 3, or 6 hours per day (hrs/d). The results pointed to a cell type-specific reaction to EMF exposure. In addition, the cellular responses were dependent on duration of EMF exposure. In the present study, cell proliferation was the trait most sensitive to EMF. EMF treatment promoted growth of hFOB 1.19 and HCN-2 compared with control cells at 7 and 14 days of incubation. When the exposure time was 3 hrs/d, EMF enhanced the proliferation of RPMI 7666 but inhibited that of T/G HA-VSMC. On the other hand, the effects of EMF on cell cycle distribution, cell differentiation, and actin distribution were unclear. Furthermore, we hardly found any correlation between EMF exposure and gap junctional intercellular communication in hFOB 1.19. This study revealed that EMF might serve as a potential tool for manipulating cell proliferation.
Files in This Item:
T200601106.pdf Download
DOI
10.3349/ymj.2006.47.6.852
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Park, Si Nae(박시내)
Suh, Hwal(서활)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/110073
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