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Antiallodynic effects of acupuncture in neuropathic rats

Authors
 Myeoung Hoon Cha  ;  Ji Soo Choi  ;  Sun Joon Bai  ;  Insop Shim  ;  Hye-jung Lee  ;  Sum Mi Choi  ;  Bae Hwan Lee  ;  Sun Mi Choi 
Citation
 YONSEI MEDICAL JOURNAL, Vol.47(3) : 359-366, 2006 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2006
MeSH
Acupuncture Analgesia* ; Animals ; Electrophysiology ; Male ; Neuralgia/physiopathology ; Neuralgia/therapy* ; Rats ; Rats, Sprague-Dawley ; Spinal Nerve Roots/physiology*
Keywords
Neuropathic pain ; acupuncture ; acupoint ; allodynia ; electrophysiology
Abstract
Peripheral nerve injury often results in abnormal neuropathic pain such as allodynia or hyperalgesia. Acupuncture, a traditional Oriental medicine, has been used to relieve pain and related symptoms. However, the efficiency of acupuncture in relieving neuropathic pain is not clear. The aim of this study was to investigate the anti-allodynic effects of acupuncture through behavioral and electrophysiological examinations. Male Sprague-Dawley rats were subjected to neuropathic surgery consisting of a tight ligation and transection of the left tibial and sural nerves, under pentobarbital anesthesia. The acupuncture experiment consisted of four different groups, one treated at each of three different acupoints (Zusanli (ST36), Yinlingquan (SP9), and a sham-acupoint) and a control group. Behavioral tests for mechanical allodynia and cold allodynia were performed for up to two weeks postoperatively. Extracellular electrophysiological recordings were made from the dorsal roots using platinum wire electrodes. Mechanical and cold allodynia were significantly reduced after acupuncture treatment at the Zusanli and Yinlingquan acupoints, respectively. Electrophysiological neural responses to von Frey and acetone tests were also reduced after acupuncture at the same two acupoints. These results suggest that acupuncture may be beneficial in relieving neuropathic pain.
Files in This Item:
T200601034.pdf Download
DOI
10.3349/ymj.2006.47.3.359
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Bai, Sun Joon(배선준) ORCID logo https://orcid.org/0000-0001-5027-3232
Lee, Bae Hwan(이배환) ORCID logo https://orcid.org/0000-0003-4719-9021
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109993
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