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Methicillin 내성 포도구균과 Vancomycin 내성 장구균에 대한 Daptomycin의 시험관내 항균력

Other Titles
 In Vitro Activities of Daptomycin Against Recent Clinical Isolates of Methicillin-resistant Staphylococci and Vancomycin-resistant Enterococci in Korea 
 이혁민  ;  박서진  ;  최영선  ;  박도영  ;  노경호  ;  염종화  ;  용동은  ;  이경원  ;  정윤섭 
 INFECTION AND CHEMOTHERAPY (감염과 화학요법), Vol.38(2) : 85-90, 2006 
Journal Title
Issue Date
Daptomycin ; MRSA ; VRE ; Staphylococci
Background: Daptomycin is a novel cyclic lipopeptide antibiotic that exhibits in vitro bactericidal activity against gram-positive pathogens including methicillin-resistant staphylococci and vancomycin-resistant enterococci. The aim of this study is to determine the in vitro activities of daptomycin against recent clinical isolates of methicillin-resistant staphylococci and vancomycin-resistant enterococci in Korea. Materials and Methods: A total of 117 clinical strains of methicillin-resistant staphylococci and vancomycin-resistant enterococci were isolated at a tertiary-care hospital in Korea in 2004. Susceptibility to daptomycin was tested by the CLSI broth microdilution method using Mueller-Hinton broth (MHB) which was adjusted to contain a final concentration of 50 μg/mL of ionized calcium (Ca2+). Susceptibilities to ampicillin, oxacillin, levofloxacin, vancomycin, and linezolid were tested by the CLSI agar dilution method. Results: All isolates of methicillin-resistant S. aureus and coagulase-negative staphylococci were inhibited by 1 μg/mL of daptomycin, and MIC90s were 1 μg/mL, which were similar to those of vancomycin and linezolid. MIC90s of daptomycin for vancomycin-resistant E. faecalis and E. faecium were 0.5 μg/mL and 2 μg/mL, respectively, and all isolates were susceptible to daptomycin. MIC90s of linezolid and levofloxacin for vancomycin-resistant enterococci were 1-2 μg/mL and 64 μg/mL, respectively. Resistance rates of vancomycin-resistant E. faecalis and E. faecium to levofloxacin were 100% and 96%, respectively. Daptomycin MICs in MHB supplemented to 20-25 μg/ml of Ca2+ were 2-8 fold higher than those in MHB supplemented to 50 μg/mL of Ca2+. Conclusion: Daptomycin is very active in vitro against methicillin-resistant staphylococci and vancomycin-resistant enterococci isolated in Korea, and it is important to test in vitro activity of daptomycin using MHB containing 50 μg/mL of Ca2+.
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1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
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