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Methicillin 내성 포도구균과 Vancomycin 내성 장구균에 대한 Daptomycin의 시험관내 항균력

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dc.contributor.author용동은-
dc.contributor.author이경원-
dc.date.accessioned2015-06-10T12:29:54Z-
dc.date.available2015-06-10T12:29:54Z-
dc.date.issued2006-
dc.identifier.issn1598-8112-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/109912-
dc.description.abstractBackground: Daptomycin is a novel cyclic lipopeptide antibiotic that exhibits in vitro bactericidal activity against gram-positive pathogens including methicillin-resistant staphylococci and vancomycin-resistant enterococci. The aim of this study is to determine the in vitro activities of daptomycin against recent clinical isolates of methicillin-resistant staphylococci and vancomycin-resistant enterococci in Korea. Materials and Methods: A total of 117 clinical strains of methicillin-resistant staphylococci and vancomycin-resistant enterococci were isolated at a tertiary-care hospital in Korea in 2004. Susceptibility to daptomycin was tested by the CLSI broth microdilution method using Mueller-Hinton broth (MHB) which was adjusted to contain a final concentration of 50 μg/mL of ionized calcium (Ca2+). Susceptibilities to ampicillin, oxacillin, levofloxacin, vancomycin, and linezolid were tested by the CLSI agar dilution method. Results: All isolates of methicillin-resistant S. aureus and coagulase-negative staphylococci were inhibited by 1 μg/mL of daptomycin, and MIC90s were 1 μg/mL, which were similar to those of vancomycin and linezolid. MIC90s of daptomycin for vancomycin-resistant E. faecalis and E. faecium were 0.5 μg/mL and 2 μg/mL, respectively, and all isolates were susceptible to daptomycin. MIC90s of linezolid and levofloxacin for vancomycin-resistant enterococci were 1-2 μg/mL and 64 μg/mL, respectively. Resistance rates of vancomycin-resistant E. faecalis and E. faecium to levofloxacin were 100% and 96%, respectively. Daptomycin MICs in MHB supplemented to 20-25 μg/ml of Ca2+ were 2-8 fold higher than those in MHB supplemented to 50 μg/mL of Ca2+. Conclusion: Daptomycin is very active in vitro against methicillin-resistant staphylococci and vancomycin-resistant enterococci isolated in Korea, and it is important to test in vitro activity of daptomycin using MHB containing 50 μg/mL of Ca2+.-
dc.description.statementOfResponsibilityopen-
dc.format.extent85~90-
dc.relation.isPartOfINFECTION AND CHEMOTHERAPY (감염과 화학요법)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleMethicillin 내성 포도구균과 Vancomycin 내성 장구균에 대한 Daptomycin의 시험관내 항균력-
dc.title.alternativeIn Vitro Activities of Daptomycin Against Recent Clinical Isolates of Methicillin-resistant Staphylococci and Vancomycin-resistant Enterococci in Korea-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학)-
dc.contributor.googleauthor이혁민-
dc.contributor.googleauthor박서진-
dc.contributor.googleauthor최영선-
dc.contributor.googleauthor박도영-
dc.contributor.googleauthor노경호-
dc.contributor.googleauthor염종화-
dc.contributor.googleauthor용동은-
dc.contributor.googleauthor이경원-
dc.contributor.googleauthor정윤섭-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02423-
dc.contributor.localIdA02649-
dc.relation.journalcodeJ01054-
dc.subject.keywordDaptomycin-
dc.subject.keywordMRSA-
dc.subject.keywordVRE-
dc.subject.keywordStaphylococci-
dc.contributor.alternativeNameYong, Dong Eun-
dc.contributor.alternativeNameLee, Kyung Won-
dc.contributor.affiliatedAuthorYong, Dong Eun-
dc.contributor.affiliatedAuthorLee, Kyung Won-
dc.rights.accessRightsfree-
dc.citation.volume38-
dc.citation.number2-
dc.citation.startPage85-
dc.citation.endPage90-
dc.identifier.bibliographicCitationINFECTION AND CHEMOTHERAPY (감염과 화학요법), Vol.38(2) : 85-90, 2006-
dc.identifier.rimsid55010-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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