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Methicillin 내성 포도구균과 Vancomycin 내성 장구균에 대한 Daptomycin의 시험관내 항균력
DC Field | Value | Language |
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dc.contributor.author | 용동은 | - |
dc.contributor.author | 이경원 | - |
dc.date.accessioned | 2015-06-10T12:29:54Z | - |
dc.date.available | 2015-06-10T12:29:54Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1598-8112 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109912 | - |
dc.description.abstract | Background: Daptomycin is a novel cyclic lipopeptide antibiotic that exhibits in vitro bactericidal activity against gram-positive pathogens including methicillin-resistant staphylococci and vancomycin-resistant enterococci. The aim of this study is to determine the in vitro activities of daptomycin against recent clinical isolates of methicillin-resistant staphylococci and vancomycin-resistant enterococci in Korea. Materials and Methods: A total of 117 clinical strains of methicillin-resistant staphylococci and vancomycin-resistant enterococci were isolated at a tertiary-care hospital in Korea in 2004. Susceptibility to daptomycin was tested by the CLSI broth microdilution method using Mueller-Hinton broth (MHB) which was adjusted to contain a final concentration of 50 μg/mL of ionized calcium (Ca2+). Susceptibilities to ampicillin, oxacillin, levofloxacin, vancomycin, and linezolid were tested by the CLSI agar dilution method. Results: All isolates of methicillin-resistant S. aureus and coagulase-negative staphylococci were inhibited by 1 μg/mL of daptomycin, and MIC90s were 1 μg/mL, which were similar to those of vancomycin and linezolid. MIC90s of daptomycin for vancomycin-resistant E. faecalis and E. faecium were 0.5 μg/mL and 2 μg/mL, respectively, and all isolates were susceptible to daptomycin. MIC90s of linezolid and levofloxacin for vancomycin-resistant enterococci were 1-2 μg/mL and 64 μg/mL, respectively. Resistance rates of vancomycin-resistant E. faecalis and E. faecium to levofloxacin were 100% and 96%, respectively. Daptomycin MICs in MHB supplemented to 20-25 μg/ml of Ca2+ were 2-8 fold higher than those in MHB supplemented to 50 μg/mL of Ca2+. Conclusion: Daptomycin is very active in vitro against methicillin-resistant staphylococci and vancomycin-resistant enterococci isolated in Korea, and it is important to test in vitro activity of daptomycin using MHB containing 50 μg/mL of Ca2+. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 85~90 | - |
dc.relation.isPartOf | INFECTION AND CHEMOTHERAPY (감염과 화학요법) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Methicillin 내성 포도구균과 Vancomycin 내성 장구균에 대한 Daptomycin의 시험관내 항균력 | - |
dc.title.alternative | In Vitro Activities of Daptomycin Against Recent Clinical Isolates of Methicillin-resistant Staphylococci and Vancomycin-resistant Enterococci in Korea | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | 이혁민 | - |
dc.contributor.googleauthor | 박서진 | - |
dc.contributor.googleauthor | 최영선 | - |
dc.contributor.googleauthor | 박도영 | - |
dc.contributor.googleauthor | 노경호 | - |
dc.contributor.googleauthor | 염종화 | - |
dc.contributor.googleauthor | 용동은 | - |
dc.contributor.googleauthor | 이경원 | - |
dc.contributor.googleauthor | 정윤섭 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02423 | - |
dc.contributor.localId | A02649 | - |
dc.relation.journalcode | J01054 | - |
dc.subject.keyword | Daptomycin | - |
dc.subject.keyword | MRSA | - |
dc.subject.keyword | VRE | - |
dc.subject.keyword | Staphylococci | - |
dc.contributor.alternativeName | Yong, Dong Eun | - |
dc.contributor.alternativeName | Lee, Kyung Won | - |
dc.contributor.affiliatedAuthor | Yong, Dong Eun | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Won | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 38 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 85 | - |
dc.citation.endPage | 90 | - |
dc.identifier.bibliographicCitation | INFECTION AND CHEMOTHERAPY (감염과 화학요법), Vol.38(2) : 85-90, 2006 | - |
dc.identifier.rimsid | 55010 | - |
dc.type.rims | ART | - |
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