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Six-week open-label trial of topiramate to treat disruptive behaviors in children and adolescents with or without mental retardation

Authors
 Cheol Shin  ;  Ho Dong  ;  M D Song  ;  Eun Hye Ha  ;  Yee Jin Shin 
Citation
 PSYCHIATRY INVESTIGATION, Vol.3(2) : 73-80, 2006 
Journal Title
 PSYCHIATRY INVESTIGATION 
ISSN
 1738-3684 
Issue Date
2006
Keywords
Topiramate ; Youth ; Disruptive behavior ; Mental retardation
Abstract
Objective: Anticonvulsants are known to be effec-tive to manage affective instability and aggressive behavior by reducing neuronal excitability. This study examined the efficacy and safety of topiramate, a novel anticonvulsant, on disruptive behavioral problems in children and adolescents, with or without mental retar-dation (MR), and the differences of short-term efficacy and safety according to the IQ levels. Methods and Materials: Fifty-four children and adolescents with disruptive behavioral problems were enrolled in a 6-week, open-label study. All subjects were divided into 3 groups (subjects without MR, Non-MR; subjects with mild MR, Mild MR; and subjects with moderate to severe MR, Mod-Severe MR) based on their intellectu-al ability, and treated with topiramate. Outcome mea-sures included the Aberrant Behavior Checklist Hyperactivity (ABC-H) and Irritability (ABC-I) sub-scales and the Clinical Global Impression Severity (CGI-S) scale. Results: Significant reduction of CGI-S, ABC-H, and ABC-I scores were noted in all three groups in the following order: Non-MR, Mild MR, and Mod-Severe MR. Parethesia, anorexia, somnolence, nocturnal enuresis, and urinary frequency were rela-tively common adverse event. However, no serious adverse events were reported. Conclusions: Topiramate was effective and well tolerated for managing disrup-tive behavioral problems and emotional instability in children and adolescents.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Song, Dong Ho(송동호) ORCID logo https://orcid.org/0000-0002-9647-3130
Shin, Yee Jin(신의진) ORCID logo https://orcid.org/0000-0001-8573-4342
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109884
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