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Six-week open-label trial of topiramate to treat disruptive behaviors in children and adolescents with or without mental retardation
DC Field | Value | Language |
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dc.contributor.author | 송동호 | - |
dc.contributor.author | 신의진 | - |
dc.date.accessioned | 2015-06-10T12:29:00Z | - |
dc.date.available | 2015-06-10T12:29:00Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1738-3684 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109884 | - |
dc.description.abstract | Objective: Anticonvulsants are known to be effec-tive to manage affective instability and aggressive behavior by reducing neuronal excitability. This study examined the efficacy and safety of topiramate, a novel anticonvulsant, on disruptive behavioral problems in children and adolescents, with or without mental retar-dation (MR), and the differences of short-term efficacy and safety according to the IQ levels. Methods and Materials: Fifty-four children and adolescents with disruptive behavioral problems were enrolled in a 6-week, open-label study. All subjects were divided into 3 groups (subjects without MR, Non-MR; subjects with mild MR, Mild MR; and subjects with moderate to severe MR, Mod-Severe MR) based on their intellectu-al ability, and treated with topiramate. Outcome mea-sures included the Aberrant Behavior Checklist Hyperactivity (ABC-H) and Irritability (ABC-I) sub-scales and the Clinical Global Impression Severity (CGI-S) scale. Results: Significant reduction of CGI-S, ABC-H, and ABC-I scores were noted in all three groups in the following order: Non-MR, Mild MR, and Mod-Severe MR. Parethesia, anorexia, somnolence, nocturnal enuresis, and urinary frequency were rela-tively common adverse event. However, no serious adverse events were reported. Conclusions: Topiramate was effective and well tolerated for managing disrup-tive behavioral problems and emotional instability in children and adolescents. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 73~80 | - |
dc.relation.isPartOf | PSYCHIATRY INVESTIGATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Six-week open-label trial of topiramate to treat disruptive behaviors in children and adolescents with or without mental retardation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Psychiatry (정신과학) | - |
dc.contributor.googleauthor | Cheol Shin | - |
dc.contributor.googleauthor | Ho Dong | - |
dc.contributor.googleauthor | M D Song | - |
dc.contributor.googleauthor | Eun Hye Ha | - |
dc.contributor.googleauthor | Yee Jin Shin | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02018 | - |
dc.contributor.localId | A02136 | - |
dc.relation.journalcode | J02569 | - |
dc.identifier.eissn | 1976-3026 | - |
dc.subject.keyword | Topiramate | - |
dc.subject.keyword | Youth | - |
dc.subject.keyword | Disruptive behavior | - |
dc.subject.keyword | Mental retardation | - |
dc.contributor.alternativeName | Song, Dong Ho | - |
dc.contributor.alternativeName | Shin, Yee Jin | - |
dc.contributor.affiliatedAuthor | Song, Dong Ho | - |
dc.contributor.affiliatedAuthor | Shin, Yee Jin | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 3 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 73 | - |
dc.citation.endPage | 80 | - |
dc.identifier.bibliographicCitation | PSYCHIATRY INVESTIGATION, Vol.3(2) : 73-80, 2006 | - |
dc.identifier.rimsid | 50660 | - |
dc.type.rims | ART | - |
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