Cited 10 times in
Hydrogen peroxide upregulates TNF-related apoptosis-inducing ligand (TRAIL) expression in human astroglial cells, and augments apoptosis of T cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최인홍 | - |
dc.date.accessioned | 2015-06-10T12:28:18Z | - |
dc.date.available | 2015-06-10T12:28:18Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109862 | - |
dc.description.abstract | The brain is particularly vulnerable to oxygen free radicals, and these radicals have been implicated in the pathology of several neurological disorders. In this study, the modulation of TNF-related apoptosis-inducing ligand (TRAIL) expression by oxidative stress was shown in LN215 cells, an astroglioma cell line. Hydrogen peroxide (H2O2) treatment increased TRAIL expression in LN215 cells and H2O2-induced TRAIL augmented apoptosis in Peer cells, a cell line sensitive to TRAIL-mediated cell death. Our findings suggest that the upregulation of TRAIL in astroglial cells may abrogate immune cell effector functions. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 551~557 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Allergy and Immunology | - |
dc.subject.MESH | Apoptosis* | - |
dc.subject.MESH | Astrocytes/metabolism* | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cyclosporine/pharmacology | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hydrogen Peroxide/pharmacology* | - |
dc.subject.MESH | Hypoxia | - |
dc.subject.MESH | Immunosuppressive Agents/pharmacology | - |
dc.subject.MESH | Oxidative Stress | - |
dc.subject.MESH | Ribonucleases/metabolism | - |
dc.subject.MESH | T-Lymphocytes/metabolism* | - |
dc.subject.MESH | TNF-Related Apoptosis-Inducing Ligand/biosynthesis* | - |
dc.subject.MESH | Up-Regulation* | - |
dc.title | Hydrogen peroxide upregulates TNF-related apoptosis-inducing ligand (TRAIL) expression in human astroglial cells, and augments apoptosis of T cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | Daeho Kwon | - |
dc.contributor.googleauthor | In-Hong Choi | - |
dc.identifier.doi | 10.3349/ymj.2006.47.4.551 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04167 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 16941746 | - |
dc.subject.keyword | Astroglial cells | - |
dc.subject.keyword | hydrogen peroxide | - |
dc.subject.keyword | TRAIL | - |
dc.subject.keyword | cyclosporin A | - |
dc.subject.keyword | apoptosis | - |
dc.subject.keyword | oxidative stress | - |
dc.subject.keyword | neuroimmunology | - |
dc.contributor.alternativeName | Choi, In Hong | - |
dc.contributor.affiliatedAuthor | Choi, In Hong | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 47 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 551 | - |
dc.citation.endPage | 557 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.47(4) : 551-557, 2006 | - |
dc.identifier.rimsid | 50645 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.