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Severe Hypothyroidism Induced by Thyroid Metastasis of Colon Adenocarcinoma: A Case Report and Review of the Literature

Authors
 Jong Chan YOUN  ;  Yumie RHEE  ;  Soo Young PARK  ;  Won Ho KIM  ;  Soo Jung KIM  ;  Hyun Cheol CHUNG  ;  Soon Won HONG  ;  Sung-Kil LIM 
Citation
 ENDOCRINE JOURNAL, Vol.53(3) : 339-343, 2006 
Journal Title
ENDOCRINE JOURNAL
ISSN
 0918-8959 
Issue Date
2006
MeSH
Adenocarcinoma/pathology ; Adenocarcinoma/secondary* ; Aged, 80 and over ; Colonic Neoplasms/pathology* ; Goiter/diagnostic imaging ; Humans ; Hypothyroidism/etiology* ; Male ; Thyroid Function Tests ; Thyroid Neoplasms/complications* ; Thyroid Neoplasms/pathology ; Thyroid Neoplasms/secondary* ; Thyrotropin/blood ; Thyroxine/blood ; Ultrasonography
Keywords
Hypothyroidism ; Metastatic thyroid cancer ; Colon adenocarcinoma ; Immunohistochemical staining ; Diagnosis
Abstract
An 85-year-old man who had undergone a right hemicolectomy for colon cancer presented with severe hypothyroidism and hoarseness 21 months after the operation. The serum thyrotropin (TSH) was markedly elevated to 118.14 μIU/mL and serum free thyroxine (fT4) level was markedly suppressed to 0.34 ng/dL. Symptoms of hoarseness and neck swelling were already evident 4 months prior at which time tests for normal thyroid function were performed. The patient was referred due to aggravated pain on his diffusely enlarged hard goiter. An enlarged thyroid with some calcification was noticed in the neck ultrasonography with multiple cervical lymphadenopathies. Core biopsy of the thyroid gland showed invasion of poorly differentiated adenocarcinoma cells. Immunohistochemical studies showed positive staining only for carcinoembryonic antigen (CEA). There were multiple lung parenchymal nodules and adrenal masses at the time of evaluation. The patient was started on palliative chemotherapy with thyroid hormone replacement and gradually became euthyroid. From these findings and the clinical observations, thyroid metastasis with hypothyroidism developing acutely from metastatic colon adenocarcinoma was diagnosed.
Files in This Item:
T200600842.pdf Download
DOI
10.1507/endocrj.K05-115
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
Rhee, Yumie(이유미) ORCID logo https://orcid.org/0000-0003-4227-5638
Lim, Sung Kil(임승길)
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
Hong, Soon Won(홍순원) ORCID logo https://orcid.org/0000-0002-0324-2414
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109778
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