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듀센형 근이영양증 환자에서의 심장 침범의 양상

Other Titles
 Cardiac Involvement in Patients with Duchenne Muscular Dystrophy 
Authors
 권성우  ;  임세중  ;  강성욱  ;  이지혁  ;  문재연  ;  박종관  ;  이성주  ;  박찬익  ;  김혜진  ;  윤영원  ;  홍범기  ;  권혁문  ;  김현승 
Citation
 Journal of Cardiovascular Ultrasound, Vol.13(4) : 152-158, 2006 
Journal Title
 Journal of Cardiovascular Ultrasound 
ISSN
 1975-4612 
Issue Date
2006
Keywords
Duchenne muscular dystrophy ; Cardiac involvement ; Echocardiography ; Electrocardiography
Abstract
Background: Cardiac involvement in Duchenne muscular dystrophy (DMD) is common, but usually latent without symptoms or signs in the initial period of disease. This study investigated the incidence and predictor of cardiac involvement in DMD patients. Method: From January 2000 to June 2005, we enrolled 45 patients with DMD (aged 20.2±3.0years) who admitted to the Yongdong Severance Hospital. Electrocardiography and transthoracic echocardiography was done to evaluate the cardiac function. Result: Electrocardiographic abnormalities were present in 80.1% of patients. Sinus tachycardia was most common (50%). LVEF was decreased (46.7±13.8%), and 56% of the patients had diastolic dysfunction. Patients with pulmonary involvement were older (20.7±3.8 vs 17.6±2.8years, p=0.028), and patients with reduced LVEF (<50%) had longer duration of disease (11.4±4.4 vs 14.3±2.4years, p=0.04). However, on multivariate analysis, age, duration of disease, pulmonary involvement, dyspnea symptom, electrocardiographic abnormality was not an independent predictor for LV systolic dysfunction in adolescent and adult patients with DMD. Conclusion: Cardiac involvement in adolescent and adult patients with DMD was frequently observed independent of age, duration of disease, pulmonary involvement, and dyspnea symptom. Therefore, more active cardiac investigation is required in patients with DMD, even without clinical suspicion.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seong Woong(강성웅) ORCID logo https://orcid.org/0000-0002-7279-3893
Kwon, Hyuck Moon(권혁문) ORCID logo https://orcid.org/0000-0001-9901-5015
Kim, Hyun Seung(김현승)
Yoon, Young Won(윤영원) ORCID logo https://orcid.org/0000-0002-0907-0350
Rim, Se Joong(임세중) ORCID logo https://orcid.org/0000-0002-7631-5581
Hong, Bum Kee(홍범기) ORCID logo https://orcid.org/0000-0002-6456-0184
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109764
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