98 164

Cited 43 times in

Association of TNFA Promoter Region Haplotype in Behçet's Disease

Authors
 KyungSook Park  ;  NaYoung Kim  ;  JungHyun Nam  ;  Dongsik Bang  ;  Eun-So Lee 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.21(4) : 596-601, 2006 
Journal Title
 JOURNAL OF KOREAN MEDICAL SCIENCE 
ISSN
 1011-8934 
Issue Date
2006
MeSH
Adolescent ; Adult ; Aged ; Behcet Syndrome/genetics* ; Behcet Syndrome/pathology ; Female ; Gene Frequency ; Genetic Predisposition to Disease/genetics ; Genotype ; Haplotypes/genetics* ; Humans ; Linkage Disequilibrium ; Male ; Middle Aged ; Odds Ratio ; Polymorphism, Single Nucleotide/genetics ; Promoter Regions, Genetic/genetics* ; Tumor Necrosis Factor-alpha/genetics*
Keywords
Tumor Necrosis Factor-alpha ; Behcet Syndrome ; Haplotypes ; Polymorphisms, Single Nucleotide
Abstract
Although the etiology of Behçet's Disease (BD; MIM 109650) remains to be clearly elucidated, levels of tumor necrosis factor alpha (TNF-α) have been reported to be significantly elevated in BD patients, and TNF-α blockers have been demonstrated to exhibit some degree of therapeutic efficacy for a certain subset of BD sufferers. In this study, we have conducted an analysis of the TNFA haplotypes in the promoter response element that affect the binding affinity of specific transcription factors, in order to characterize their association with the clinical features of BD. Six polymorphisms in the promoter region of TNFA were genotyped in 254 BD patients and 344 control subjects, via the PCR-RFLP technique. TNFA -1031*C, -863*A and -308*G alleles were associated with an increased risk of BD (p=0.030, OR=1.4; p=0.008, OR=1.5; p=0.010, OR=1.8, respectively). The sole TNFA haplotype -1031C-863A-857C-376G-308G-238G, was associated with a 1.6 fold increase in the risk of BD, whereas the TNFA haplotype -1031T-863C-857C-376G-308A-238G was associated with a 0.6 decreased risk of BD. The TNFA -1031*C, -863*A, -857*C and -308*G alleles were significantly associated with BD. The findings of this study, collectively, indicate that TNFA haplotypes in the promoter response elements may exert significant influence on susceptibility to BD.
Files in This Item:
T200600805.pdf Download
DOI
10.3346/jkms.2006.21.4.596
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Bang, Dong Sik(방동식)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109733
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse