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Association of TNFA Promoter Region Haplotype in Behçet's Disease

DC FieldValueLanguage
dc.contributor.author방동식-
dc.date.accessioned2015-06-10T12:24:03Z-
dc.date.available2015-06-10T12:24:03Z-
dc.date.issued2006-
dc.identifier.issn1011-8934-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/109733-
dc.description.abstractAlthough the etiology of Behçet's Disease (BD; MIM 109650) remains to be clearly elucidated, levels of tumor necrosis factor alpha (TNF-α) have been reported to be significantly elevated in BD patients, and TNF-α blockers have been demonstrated to exhibit some degree of therapeutic efficacy for a certain subset of BD sufferers. In this study, we have conducted an analysis of the TNFA haplotypes in the promoter response element that affect the binding affinity of specific transcription factors, in order to characterize their association with the clinical features of BD. Six polymorphisms in the promoter region of TNFA were genotyped in 254 BD patients and 344 control subjects, via the PCR-RFLP technique. TNFA -1031*C, -863*A and -308*G alleles were associated with an increased risk of BD (p=0.030, OR=1.4; p=0.008, OR=1.5; p=0.010, OR=1.8, respectively). The sole TNFA haplotype -1031C-863A-857C-376G-308G-238G, was associated with a 1.6 fold increase in the risk of BD, whereas the TNFA haplotype -1031T-863C-857C-376G-308A-238G was associated with a 0.6 decreased risk of BD. The TNFA -1031*C, -863*A, -857*C and -308*G alleles were significantly associated with BD. The findings of this study, collectively, indicate that TNFA haplotypes in the promoter response elements may exert significant influence on susceptibility to BD.-
dc.description.statementOfResponsibilityopen-
dc.format.extent596~601-
dc.relation.isPartOfJOURNAL OF KOREAN MEDICAL SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBehcet Syndrome/genetics*-
dc.subject.MESHBehcet Syndrome/pathology-
dc.subject.MESHFemale-
dc.subject.MESHGene Frequency-
dc.subject.MESHGenetic Predisposition to Disease/genetics-
dc.subject.MESHGenotype-
dc.subject.MESHHaplotypes/genetics*-
dc.subject.MESHHumans-
dc.subject.MESHLinkage Disequilibrium-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOdds Ratio-
dc.subject.MESHPolymorphism, Single Nucleotide/genetics-
dc.subject.MESHPromoter Regions, Genetic/genetics*-
dc.subject.MESHTumor Necrosis Factor-alpha/genetics*-
dc.titleAssociation of TNFA Promoter Region Haplotype in Behçet's Disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Dermatology (피부과학)-
dc.contributor.googleauthorKyungSook Park-
dc.contributor.googleauthorNaYoung Kim-
dc.contributor.googleauthorJungHyun Nam-
dc.contributor.googleauthorDongsik Bang-
dc.contributor.googleauthorEun-So Lee-
dc.identifier.doi10.3346/jkms.2006.21.4.596-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01784-
dc.relation.journalcodeJ01517-
dc.identifier.eissn1598-6357-
dc.identifier.pmid16891799-
dc.subject.keywordTumor Necrosis Factor-alpha-
dc.subject.keywordBehcet Syndrome-
dc.subject.keywordHaplotypes-
dc.subject.keywordPolymorphisms, Single Nucleotide-
dc.contributor.alternativeNameBang, Dong Sik-
dc.contributor.affiliatedAuthorBang, Dong Sik-
dc.rights.accessRightsfree-
dc.citation.volume21-
dc.citation.number4-
dc.citation.startPage596-
dc.citation.endPage601-
dc.identifier.bibliographicCitationJOURNAL OF KOREAN MEDICAL SCIENCE, Vol.21(4) : 596-601, 2006-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers

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