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Association of aortic plaque with intracranial atherosclerosis in patients with stroke

 H. S. Nam  ;  S. W. Han  ;  J. Y. Lee  ;  S. H. Ahn  ;  J. W. Ha  ;  S. J. Rim  ;  B. I. Lee  ;  J. H. Heo 
 NEUROLOGY, Vol.67(7) : 1184-1188, 2006 
Journal Title
Issue Date
Aged ; Aortic Valve Stenosis/diagnosis ; Aortic Valve Stenosis/epidemiology* ; Comorbidity ; Female ; Humans ; Intracranial Arteriosclerosis/diagnosis ; Intracranial Arteriosclerosis/epidemiology* ; Korea/epidemiology ; Male ; Middle Aged ; Prevalence ; Retrospective Studies ; Risk Assessment/methods* ; Risk Factors ; Stroke/diagnosis ; Stroke/epidemiology*
OBJECTIVE: To determine whether there is a relationship between aortic plaques and intracranial (IC) atherosclerosis. METHODS: We reviewed 922 patients with stroke who had both transesophageal echocardiography and cerebral angiography. The plaques of these patients were classified as either complex aortic plaques (CAP), which protruded > or =4 mm or were present as mobile lesions in the proximal aorta, or simple aortic plaques (SAP), which were <4 mm or present in the descending aorta. Cerebral artery atherosclerosis was classified as either an IC or extracranial (EC) atherosclerosis. RESULTS: Among the 922 patients, we found aortic plaques in 237 patients (26%). There were 111 (47%) patients of SAP, 74 (31%) patients with CAP, and 52 (22%) patients that had both SAP and CAP. Angiography showed IC or EC atherosclerosis in 511 patients (55%). The presence of aortic plaques was significantly associated with IC or EC atherosclerosis. The significance appeared to be due to the strong association between the presence of SAP and IC atherosclerosis (51% SAP vs 35% no plaques; odds ratio = 1.94, 95% CI: 1.17 to 3.21). In the multiple logistic regression analysis, SAP were independent predictors of IC atherosclerosis CONCLUSIONS: The presence of simple aortic plaques may be a marker of advanced vascular disease. Detection of simple aortic plaques during transesophageal echocardiography may have clinical implications because patients with these plaques frequently had concomitant intracranial atherosclerosis, a risk factor for stroke.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Byung In(이병인)
Rim, Se Joong(임세중) ORCID logo https://orcid.org/0000-0002-7631-5581
Ha, Jong Won(하종원) ORCID logo https://orcid.org/0000-0002-8260-2958
Heo, Ji Hoe(허지회) ORCID logo https://orcid.org/0000-0001-9898-3321
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