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제2형 당뇨병환자에서의 인슐린양 성장인자 결합단백질-3(IGFBP-3) promoter -202 A/C 유전자 다형성

Other Titles
 Genetic Polymorphism of Insulin-like Growth Factor Binding Proein-3(IGBP-3) Promoter Gene in Type 2 DM patients 
 남지선  ;  공지현  ;  노태웅  ;  김철식  ;  박종숙  ;  김혜진  ;  최유경  ;  임재윤  ;  강은석  ;  안철우  ;  차봉수  ;  이은직  ;  임승길  ;  김경래  ;  이현철 
 Clinical Diabetes (임상당뇨병), Vol.7(2) : 169-180, 2006 
Journal Title
 Clinical Diabetes (임상당뇨병) 
Issue Date
Insulin-like growth factor ; Insulin-like growth factor binding protein-3 ; Insulin-like growth factor binding protein-3 promoter -202 polymorphism ; Type 2 diabetes mellitus
Backgrounds: IGFs share approximately 50 percent of their amino acid with insulin and are largely bound to IGFBP-3, and they are known to be important in glucose metabolism. We evaluated the impact of IGFBP-3 promoter-202 polymorphism on concentration of IGF-I and IGFBP-3, and its relationship with different clinical characteristics of type 2 diabetes (T2DM). Method: A single nucleotide polymorphism at -202 locus of the IGFBP-3 promoter was genotyped for T2DM patients and the controls in their forties. Then, we compared concentrations of IGF-I and IGFBP-3, IGFBP-3 promoter-202 polymorphisms, and other clinical characteristics between diabetes group and the control. Results: Total of 169 subjects were enrolled. IGF-I levels of diabetes group were lower than those of the control, while IGFBP-3 levels of diabetes group were higher than the control. Among IGFBP-3 promoter -202 polymorphisms, AA occurred in 31 subjects (42.5%), AC in 33 (45.2%), and CC in 20 (27.4%) in control group. IGFBP-3 level was highest in AA group and lowest in CC group, and, IGF-I/IGFBP-3 molar ratio was lower in AA group than AC and CC groups. In diabetes group, AA occurred in 42 patients (50%) and AC in 42 patients (50%) without any significant difference between the two groups. IGF-I was in a negative correlation with weight, height, BMI and FBS. And IGFBP-3 correlated positively with BMI, FBS, and cholesterol. Conclusion: T2DM patients had decreased levels of IGF-I and increased levels of IGFBP-3, which can reduce IGF-I/IGFBP-3 molar ratio and free IGF-I. In other words, low free IGF-I level can give rise to T2DM. IGFBP-3 promoter -202 genotype has a control over concentration of IGFBP-3, but not weight, height, and BMI. However, IGFBP-3 is in a positive correlation with BMI. Thus, we propose that IGFBP-3 promoter -202 genotype may influence glucose metabolism not only by directly controlling IGFBP-3 concentration, but also through BMI indirectly.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Kim, Kyung Rae(김경래)
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Eun Jig(이은직) ORCID logo https://orcid.org/0000-0002-9876-8370
Lee, Hyun Chul(이현철)
Lim, Sung Kil(임승길)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
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