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제2형 당뇨병환자에서의 인슐린양 성장인자 결합단백질-3(IGFBP-3) promoter -202 A/C 유전자 다형성
DC Field | Value | Language |
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dc.contributor.author | 강은석 | - |
dc.contributor.author | 김경래 | - |
dc.contributor.author | 안철우 | - |
dc.contributor.author | 이은직 | - |
dc.contributor.author | 이현철 | - |
dc.contributor.author | 임승길 | - |
dc.contributor.author | 차봉수 | - |
dc.date.accessioned | 2015-06-10T12:22:09Z | - |
dc.date.available | 2015-06-10T12:22:09Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1229-9693 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109674 | - |
dc.description.abstract | Backgrounds: IGFs share approximately 50 percent of their amino acid with insulin and are largely bound to IGFBP-3, and they are known to be important in glucose metabolism. We evaluated the impact of IGFBP-3 promoter-202 polymorphism on concentration of IGF-I and IGFBP-3, and its relationship with different clinical characteristics of type 2 diabetes (T2DM). Method: A single nucleotide polymorphism at -202 locus of the IGFBP-3 promoter was genotyped for T2DM patients and the controls in their forties. Then, we compared concentrations of IGF-I and IGFBP-3, IGFBP-3 promoter-202 polymorphisms, and other clinical characteristics between diabetes group and the control. Results: Total of 169 subjects were enrolled. IGF-I levels of diabetes group were lower than those of the control, while IGFBP-3 levels of diabetes group were higher than the control. Among IGFBP-3 promoter -202 polymorphisms, AA occurred in 31 subjects (42.5%), AC in 33 (45.2%), and CC in 20 (27.4%) in control group. IGFBP-3 level was highest in AA group and lowest in CC group, and, IGF-I/IGFBP-3 molar ratio was lower in AA group than AC and CC groups. In diabetes group, AA occurred in 42 patients (50%) and AC in 42 patients (50%) without any significant difference between the two groups. IGF-I was in a negative correlation with weight, height, BMI and FBS. And IGFBP-3 correlated positively with BMI, FBS, and cholesterol. Conclusion: T2DM patients had decreased levels of IGF-I and increased levels of IGFBP-3, which can reduce IGF-I/IGFBP-3 molar ratio and free IGF-I. In other words, low free IGF-I level can give rise to T2DM. IGFBP-3 promoter -202 genotype has a control over concentration of IGFBP-3, but not weight, height, and BMI. However, IGFBP-3 is in a positive correlation with BMI. Thus, we propose that IGFBP-3 promoter -202 genotype may influence glucose metabolism not only by directly controlling IGFBP-3 concentration, but also through BMI indirectly. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 169~180 | - |
dc.relation.isPartOf | Clinical Diabetes (임상당뇨병) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 제2형 당뇨병환자에서의 인슐린양 성장인자 결합단백질-3(IGFBP-3) promoter -202 A/C 유전자 다형성 | - |
dc.title.alternative | Genetic Polymorphism of Insulin-like Growth Factor Binding Proein-3(IGBP-3) Promoter Gene in Type 2 DM patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | 남지선 | - |
dc.contributor.googleauthor | 공지현 | - |
dc.contributor.googleauthor | 노태웅 | - |
dc.contributor.googleauthor | 김철식 | - |
dc.contributor.googleauthor | 박종숙 | - |
dc.contributor.googleauthor | 김혜진 | - |
dc.contributor.googleauthor | 최유경 | - |
dc.contributor.googleauthor | 임재윤 | - |
dc.contributor.googleauthor | 강은석 | - |
dc.contributor.googleauthor | 안철우 | - |
dc.contributor.googleauthor | 차봉수 | - |
dc.contributor.googleauthor | 이은직 | - |
dc.contributor.googleauthor | 임승길 | - |
dc.contributor.googleauthor | 김경래 | - |
dc.contributor.googleauthor | 이현철 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00068 | - |
dc.contributor.localId | A00294 | - |
dc.contributor.localId | A02270 | - |
dc.contributor.localId | A03050 | - |
dc.contributor.localId | A03301 | - |
dc.contributor.localId | A03375 | - |
dc.contributor.localId | A03996 | - |
dc.relation.journalcode | J00568 | - |
dc.subject.keyword | Insulin-like growth factor | - |
dc.subject.keyword | Insulin-like growth factor binding protein-3 | - |
dc.subject.keyword | Insulin-like growth factor binding protein-3 promoter -202 polymorphism | - |
dc.subject.keyword | Type 2 diabetes mellitus | - |
dc.contributor.alternativeName | Kang, Eun Seok | - |
dc.contributor.alternativeName | Kim, Kyung Rae | - |
dc.contributor.alternativeName | Ahn, Chul Woo | - |
dc.contributor.alternativeName | Lee, Eun Jig | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Lim, Sung Kil | - |
dc.contributor.alternativeName | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | Kang, Eun Seok | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Rae | - |
dc.contributor.affiliatedAuthor | Ahn, Chul Woo | - |
dc.contributor.affiliatedAuthor | Lee, Eun Jig | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Chul | - |
dc.contributor.affiliatedAuthor | Lim, Sung Kil | - |
dc.contributor.affiliatedAuthor | Cha, Bong Soo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 7 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 169 | - |
dc.citation.endPage | 180 | - |
dc.identifier.bibliographicCitation | Clinical Diabetes (임상당뇨병), Vol.7(2) : 169-180, 2006 | - |
dc.identifier.rimsid | 38913 | - |
dc.type.rims | ART | - |
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