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Adverse effect of splenectomy on recurrence in total gastrectomy cancer patients with perioperative transfusion

Authors
 Jian Guo Shen  ;  Jae Ho Cheong  ;  Woo Jin Hyung  ;  Junuk Kim  ;  Seung Ho Choi  ;  Sung Hoon Noh 
Citation
 AMERICAN JOURNAL OF SURGERY, Vol.192(3) : 301-305, 2006 
Journal Title
AMERICAN JOURNAL OF SURGERY
ISSN
 0002-9610 
Issue Date
2006
MeSH
Adenocarcinoma/mortality ; Adenocarcinoma/pathology ; Adenocarcinoma/surgery* ; Adult ; Aged ; Blood Transfusion* ; Female ; Gastrectomy* ; Humans ; Intraoperative Care ; Male ; Middle Aged ; Neoplasm Recurrence, Local/etiology* ; Neoplasm Recurrence, Local/mortality ; Retrospective Studies ; Risk Factors ; Splenectomy/adverse effects* ; Stomach Neoplasms/mortality ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery* ; Survival Rate
Keywords
Transfusion ; Splenectomy ; Gastric cancer ; Prognosis
Abstract
BACKGROUND: To investigate the interactions between splenectomy and perioperative transfusion in gastric cancer patients. METHODS: Medical records of 449 gastric cancer patients who had undergone total gastrectomies for curative intent between 1991 and 1995 were reviewed. The influence of splenectomy on tumor recurrence and survival both in the transfused and nontransfused patients were evaluated by univariate and multivariate analysis. RESULTS: The recurrence rate in the splenectomy group was 48.1% as compared with 22.6% in the spleen-preserved group among transfused patients (P=.001); it was 40.7% compared with 26.5% among nontransfused patients (P=.086). There was no significant difference in the mean survival between the splenectomy group and the spleen-preserved group in a subgroup analysis by stage. Multivariate analysis identified splenectomy as an independent risk factor for recurrence but not as a predictor for survival among transfused patients. CONCLUSIONS: Splenectomy does not appear to abrogate the adverse effect of perioperative transfusion on prognosis in gastric cancer patients. Moreover, it may increase postoperative recurrence in transfused patients.
Full Text
http://www.sciencedirect.com/science/article/pii/S0002961006003710
DOI
10.1016/j.amjsurg.2006.04.014
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Cheong, Jae Ho(정재호) ORCID logo https://orcid.org/0000-0002-1703-1781
Choi, Seung Ho(최승호) ORCID logo https://orcid.org/0000-0002-9872-3594
Hyung, Woo Jin(형우진) ORCID logo https://orcid.org/0000-0002-8593-9214
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109654
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