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전기방사 나노섬유막을 이용한 배양 피부대체물의 제조 및 평가

Other Titles
 Electrospun Nanofibrous Membranes for the Engineering of Cultured Skin Substitutes 
 박시내  ;  김정환  ;  김일훈  ;  설아람  ;  서활 
 Biomaterials Research (생체재료학회지), Vol.10(2) : 82-88, 2006 
Journal Title
Biomaterials Research(생체재료학회지)
Issue Date
Skin substitute ; Collagen ; PLGA ; Electrospun nanofiber ; Biocompatibility
In this study, nanofibrous membranes from biodegradable PLGA and collagen were fabricated to mimic natural extracellular matrix (ECM) and investigated on the morphology, conformational stability, cytotoxicity and cell attachment. The effect of PLGA or collagen nanofibrous membranes incorporating human dermal fibroblasts on wound healing was also evaluated using an in vivo full thickness dermal defect model. The circular dichroism measurements showed that electrospun collagen maintained its triple helix structure. In cytotoxicity test using L929 fibroblastic cells, electrospun PLGA or collagen nanofibrous membrane demonstrated no significant toxicity. It was also found that collagen and PLGA nanofibers favored cell attachment and proliferation. In vivo testing showed that the regeneration of dermis and epidermis treated with PLGA or collagen nanofibrous membrane incorporating dermal fibroblasts was accelerated. Therefore, this electrospun PLGA or collagen nanofibrous membrane might have potential efficacy in tissue engineering as skin substitutes.
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1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Park, Si Nae(박시내)
Suh, Hwal(서활)
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