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Influence of a microscopic positive proximal margin in the treatment of gastric adenocarcinoma of the cardia

Authors
 Jian-Guo Shen  ;  Jae-Ho Cheong  ;  Woo-Jin Hyung  ;  Junuk Kim  ;  Seung-Ho Choi and Sung-Hoon Noh 
Citation
 WORLD JOURNAL OF GASTROENTEROLOGY, Vol.12(24) : 3883-3886, 2006 
Journal Title
WORLD JOURNAL OF GASTROENTEROLOGY
ISSN
 1007-9327 
Issue Date
2006
MeSH
Adenocarcinoma/pathology* ; Adenocarcinoma/surgery* ; Adult ; Aged ; Aged, 80 and over ; Cardia/pathology* ; Cardia/surgery ; Disease-Free Survival ; Female ; Gastrectomy/methods* ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasm Invasiveness/pathology ; Neoplasm Recurrence, Local/prevention & control ; Neoplasm, Residual ; Prognosis ; Retrospective Studies ; Stomach Neoplasms/pathology* ; Stomach Neoplasms/surgery* ; Survival Analysis
Keywords
Resection margin ; Gastric cancer ; Total gastrectomy ; Outcome
Abstract
AIM: To investigate the influence of a positive proximal margin in total gastrectomy patients with gastric adenocarcinoma of the cardia. METHODS: Medical records of 191 patients with total gastrectomies for adenocarcinoma of the cardia between 1995 and 2000 were reviewed. The clinicopathologic features associated with a positive margin were determined, and the predictors for survival were analyzed. RESULTS: The incidence of positive proximal margin was 8.4% (16/191). The positive margins were associated with advanced diseases. The tumor size and the depth of tumor invasion were independent risk factors for a positive margin. The mean survival in the positive margin group was 33.9 mo as compared with 62.4 mo in the negative group (P < 0.001). However, the difference in survival lost significance in subgroup analysis according to stage. Multivariate analysis identified that a positive margin was not an independent prognostic factor for survival. CONCLUSION: A positive margin is more of an indication of advanced disease in patients with gastric adenocarcinoma of the cardia rather than an independent prognostic factor for survival.
Files in This Item:
T200600693.pdf Download
DOI
10.3748/wjg.v12.i24.3883
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Cheong, Jae Ho(정재호) ORCID logo https://orcid.org/0000-0002-1703-1781
Choi, Seung Ho(최승호) ORCID logo https://orcid.org/0000-0002-9872-3594
Hyung, Woo Jin(형우진) ORCID logo https://orcid.org/0000-0002-8593-9214
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109598
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