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Newfactan®, Surfacten®, Exosurf®의 물리적, 생물적 활성도 비교

Other Titles
 Comparisons of Physical and Biological Activities between Newfactan®, Surfacten®, Exosurf® 
Authors
 이동우  ;  박민수  ;  전지현  ;  최은나  ;  박국인  ;  남궁란  ;  이철 
Citation
 Journal of the Korean Society of Neonatology (대한신생아학회지), Vol.13(1) : 1-8, 2006 
Journal Title
 Journal of the Korean Society of Neonatology (대한신생아학회지) 
ISSN
 1226-1513 
Issue Date
2006
Keywords
Pulmonary surfactant ; Surface tension ; Hysteresis ; Pressure-Volume curve
Abstract
Purpose: Neonatal respiratory distress syndrome (RDS) is caused by the deficiency of pulmonary surfactants in the newborn. We aim to determine and compare the physical and biological activities of the three surfactants currently on the market, namely Newfactan®, Surfacten® and Exosurf®. Methods: For physical activities, we performed the stable microbubble test (SMR) and Pulsating Bubble Surfactometer (PBS). The minimum and maximum surface tensions measured at 1 and 5 minutes allowed us to create the surface-tension diagrams, from which the compressibility at a surface tension of 10 mN/m was calculated for all three products. The biological activities were compared using the pressure-volume curves measured from premature rabbit fetuses. Results: For all three products, the concentration of surfactant and the number of stable microbubbles exhibited a proportional increase in relationship. For both Newfactan® and Surfacten®, the minimal surface tensions were lower than 10 mN/m at 1 and 5 minutes. Hysteresis was evident at 1 and 5 minutes for both Newfactan® and Surfacten®, and their surface tensions were reduced below 10 mN/m at 20% surface compression. As for Exosurf®, all the hysteresis measurements were below expectations, and the reduction in surface tension during compression was also minimal. The compressibilities at a surface tension of 10 mN/m and measured at 1 and 5 minutes for Newfactan® and Surfacten® were less than 0.020 cm/dyne at almost concentrations. The pulmonary surface areas of the fetal rabbits were, after aeration by a maximum of 30 cmH2O, adequately maintained after decompression to 5 cmH2O in the groups treated with Newfactan® and Surfacten®. However, the lung volume was not maintained upon decompression to 5 cmH2O in the groups treated with Exosurf®. Conclusions: Newfactan®and Surfacten® were effective agents in prevention of pulmonary collapse in premature lungs.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Namgung, Ran(남궁란) ORCID logo https://orcid.org/0000-0001-7182-9535
Park, Kook In(박국인) ORCID logo https://orcid.org/0000-0001-8499-9293
Park, Min Soo(박민수) ORCID logo https://orcid.org/0000-0002-4395-9938
Lee, Chul(이철)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109467
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