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15-Lipoxygenase-1 induced by interleukin-4 mediates apoptosis in oral cavity cancer cells

Authors
 Jeong Hong Kim  ;  Jung Hyun Chang  ;  Joo-Heon Yoon  ;  Jeung Gweon Lee  ;  Jung Ho Bae  ;  Kyung-Su Kim 
Citation
 Oral Oncology, Vol.42(8) : 825-830, 2006 
Journal Title
 Oral Oncology 
ISSN
 1368-8375 
Issue Date
2006
MeSH
Apoptosis/drug effects* ; Apoptosis/physiology ; Arachidonate 15-Lipoxygenase/genetics ; Arachidonate 15-Lipoxygenase/physiology* ; Blotting, Western/methods ; Caffeic Acids/pharmacology ; Carcinoma, Squamous Cell/enzymology ; Carcinoma, Squamous Cell/pathology* ; Caspases/physiology ; Cell Proliferation/drug effects ; Dose-Response Relationship, Immunologic ; Gene Expression Regulation, Enzymologic/drug effects ; Humans ; Interleukin-4/pharmacology* ; Mouth Neoplasms/enzymology ; Mouth Neoplasms/pathology* ; RNA, Messenger/genetics ; Reverse Transcriptase Polymerase Chain Reaction/methods ; Tumor Cells, Cultured
Keywords
Interleukin-4 ; Oral cavity cancer ; 15-Lipoxygenase-1 ; Apoptosis
Abstract
It is unknown whether IL-4 induces apoptosis in oral cavity cancer (OCC) cells and, if so, what the mediator of this apoptosis is. Therefore, this study investigated whether apoptosis of OCC cells is induced by IL-4 and whether 15-lipoxygenase-1 (15-LO-1), induced by IL-4, is the mediator of this apoptosis. SCC 1483 oral cavity cancer cells were used in these experiments, and flow cytometry and PARP cleavage were used to examine apoptosis. At an IL-4 dosage that inhibited 50% of cell proliferation, apoptosis was observed, and this apoptosis was inhibited by 2.2 μM caffeic acid (CA). 15-LO-1 mRNA expression was observed beginning at 8 h after treatment with IL-4, and apoptosis increased after 24 h treatment with IL-4. In this apoptosis, the caspase cascade was not involved. In summary, IL-4 induced apoptosis in SCC 1483 OCC cells, and 15-LO-1, induced by IL-4, may mediate this apoptotic pathway.
Full Text
http://www.sciencedirect.com/science/article/pii/S1368837505003453
DOI
10.1016/j.oraloncology.2005.12.004
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Su(김경수) ORCID logo https://orcid.org/0000-0003-1460-0640
Yoon, Joo Heon(윤주헌)
Lee, Jeung Gweon(이정권)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109400
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