Cited 11 times in
15-Lipoxygenase-1 induced by interleukin-4 mediates apoptosis in oral cavity cancer cells
DC Field | Value | Language |
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dc.contributor.author | 김경수 | - |
dc.contributor.author | 윤주헌 | - |
dc.contributor.author | 이정권 | - |
dc.date.accessioned | 2015-06-10T12:13:03Z | - |
dc.date.available | 2015-06-10T12:13:03Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1368-8375 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109400 | - |
dc.description.abstract | It is unknown whether IL-4 induces apoptosis in oral cavity cancer (OCC) cells and, if so, what the mediator of this apoptosis is. Therefore, this study investigated whether apoptosis of OCC cells is induced by IL-4 and whether 15-lipoxygenase-1 (15-LO-1), induced by IL-4, is the mediator of this apoptosis. SCC 1483 oral cavity cancer cells were used in these experiments, and flow cytometry and PARP cleavage were used to examine apoptosis. At an IL-4 dosage that inhibited 50% of cell proliferation, apoptosis was observed, and this apoptosis was inhibited by 2.2 μM caffeic acid (CA). 15-LO-1 mRNA expression was observed beginning at 8 h after treatment with IL-4, and apoptosis increased after 24 h treatment with IL-4. In this apoptosis, the caspase cascade was not involved. In summary, IL-4 induced apoptosis in SCC 1483 OCC cells, and 15-LO-1, induced by IL-4, may mediate this apoptotic pathway. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 825~830 | - |
dc.language | ORAL ONCOLOGY | - |
dc.publisher | ORAL ONCOLOGY | - |
dc.relation.isPartOf | ORAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Apoptosis/drug effects* | - |
dc.subject.MESH | Apoptosis/physiology | - |
dc.subject.MESH | Arachidonate 15-Lipoxygenase/genetics | - |
dc.subject.MESH | Arachidonate 15-Lipoxygenase/physiology* | - |
dc.subject.MESH | Blotting, Western/methods | - |
dc.subject.MESH | Caffeic Acids/pharmacology | - |
dc.subject.MESH | Carcinoma, Squamous Cell/enzymology | - |
dc.subject.MESH | Carcinoma, Squamous Cell/pathology* | - |
dc.subject.MESH | Caspases/physiology | - |
dc.subject.MESH | Cell Proliferation/drug effects | - |
dc.subject.MESH | Dose-Response Relationship, Immunologic | - |
dc.subject.MESH | Gene Expression Regulation, Enzymologic/drug effects | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interleukin-4/pharmacology* | - |
dc.subject.MESH | Mouth Neoplasms/enzymology | - |
dc.subject.MESH | Mouth Neoplasms/pathology* | - |
dc.subject.MESH | RNA, Messenger/genetics | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction/methods | - |
dc.subject.MESH | Tumor Cells, Cultured | - |
dc.title | 15-Lipoxygenase-1 induced by interleukin-4 mediates apoptosis in oral cavity cancer cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Otorhinolaryngology (이비인후과학) | - |
dc.contributor.googleauthor | Jeong Hong Kim | - |
dc.contributor.googleauthor | Jung Hyun Chang | - |
dc.contributor.googleauthor | Joo-Heon Yoon | - |
dc.contributor.googleauthor | Jeung Gweon Lee | - |
dc.contributor.googleauthor | Jung Ho Bae | - |
dc.contributor.googleauthor | Kyung-Su Kim | - |
dc.identifier.doi | 10.1016/j.oraloncology.2005.12.004 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00298 | - |
dc.contributor.localId | A02604 | - |
dc.contributor.localId | A03095 | - |
dc.relation.journalcode | J02440 | - |
dc.identifier.eissn | 1879-0593 | - |
dc.identifier.pmid | 16472553 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1368837505003453 | - |
dc.subject.keyword | Interleukin-4 | - |
dc.subject.keyword | Oral cavity cancer | - |
dc.subject.keyword | 15-Lipoxygenase-1 | - |
dc.subject.keyword | Apoptosis | - |
dc.contributor.alternativeName | Kim, Kyung Su | - |
dc.contributor.alternativeName | Yoon, Joo Heon | - |
dc.contributor.alternativeName | Lee, Jeung Gweon | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Su | - |
dc.contributor.affiliatedAuthor | Yoon, Joo Heon | - |
dc.contributor.affiliatedAuthor | Lee, Jeung Gweon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 42 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 825 | - |
dc.citation.endPage | 830 | - |
dc.identifier.bibliographicCitation | ORAL ONCOLOGY, Vol.42(8) : 825-830, 2006 | - |
dc.identifier.rimsid | 57360 | - |
dc.type.rims | ART | - |
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