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15-Lipoxygenase-1 induced by interleukin-4 mediates apoptosis in oral cavity cancer cells

DC Field Value Language
dc.contributor.author김경수-
dc.contributor.author윤주헌-
dc.contributor.author이정권-
dc.date.accessioned2015-06-10T12:13:03Z-
dc.date.available2015-06-10T12:13:03Z-
dc.date.issued2006-
dc.identifier.issn1368-8375-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/109400-
dc.description.abstractIt is unknown whether IL-4 induces apoptosis in oral cavity cancer (OCC) cells and, if so, what the mediator of this apoptosis is. Therefore, this study investigated whether apoptosis of OCC cells is induced by IL-4 and whether 15-lipoxygenase-1 (15-LO-1), induced by IL-4, is the mediator of this apoptosis. SCC 1483 oral cavity cancer cells were used in these experiments, and flow cytometry and PARP cleavage were used to examine apoptosis. At an IL-4 dosage that inhibited 50% of cell proliferation, apoptosis was observed, and this apoptosis was inhibited by 2.2 μM caffeic acid (CA). 15-LO-1 mRNA expression was observed beginning at 8 h after treatment with IL-4, and apoptosis increased after 24 h treatment with IL-4. In this apoptosis, the caspase cascade was not involved. In summary, IL-4 induced apoptosis in SCC 1483 OCC cells, and 15-LO-1, induced by IL-4, may mediate this apoptotic pathway.-
dc.description.statementOfResponsibilityopen-
dc.format.extent825~830-
dc.relation.isPartOfORAL ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHApoptosis/drug effects*-
dc.subject.MESHApoptosis/physiology-
dc.subject.MESHArachidonate 15-Lipoxygenase/genetics-
dc.subject.MESHArachidonate 15-Lipoxygenase/physiology*-
dc.subject.MESHBlotting, Western/methods-
dc.subject.MESHCaffeic Acids/pharmacology-
dc.subject.MESHCarcinoma, Squamous Cell/enzymology-
dc.subject.MESHCarcinoma, Squamous Cell/pathology*-
dc.subject.MESHCaspases/physiology-
dc.subject.MESHCell Proliferation/drug effects-
dc.subject.MESHDose-Response Relationship, Immunologic-
dc.subject.MESHGene Expression Regulation, Enzymologic/drug effects-
dc.subject.MESHHumans-
dc.subject.MESHInterleukin-4/pharmacology*-
dc.subject.MESHMouth Neoplasms/enzymology-
dc.subject.MESHMouth Neoplasms/pathology*-
dc.subject.MESHRNA, Messenger/genetics-
dc.subject.MESHReverse Transcriptase Polymerase Chain Reaction/methods-
dc.subject.MESHTumor Cells, Cultured-
dc.title15-Lipoxygenase-1 induced by interleukin-4 mediates apoptosis in oral cavity cancer cells-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Otorhinolaryngology (이비인후과학)-
dc.contributor.googleauthorJeong Hong Kim-
dc.contributor.googleauthorJung Hyun Chang-
dc.contributor.googleauthorJoo-Heon Yoon-
dc.contributor.googleauthorJeung Gweon Lee-
dc.contributor.googleauthorJung Ho Bae-
dc.contributor.googleauthorKyung-Su Kim-
dc.identifier.doi10.1016/j.oraloncology.2005.12.004-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00298-
dc.contributor.localIdA02604-
dc.contributor.localIdA03095-
dc.relation.journalcodeJ02440-
dc.identifier.eissn1879-0593-
dc.identifier.pmid16472553-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S1368837505003453-
dc.subject.keywordInterleukin-4-
dc.subject.keywordOral cavity cancer-
dc.subject.keyword15-Lipoxygenase-1-
dc.subject.keywordApoptosis-
dc.contributor.alternativeNameKim, Kyung Su-
dc.contributor.alternativeNameYoon, Joo Heon-
dc.contributor.alternativeNameLee, Jeung Gweon-
dc.contributor.affiliatedAuthorKim, Kyung Su-
dc.contributor.affiliatedAuthorYoon, Joo Heon-
dc.contributor.affiliatedAuthorLee, Jeung Gweon-
dc.rights.accessRightsnot free-
dc.citation.volume42-
dc.citation.number8-
dc.citation.startPage825-
dc.citation.endPage830-
dc.identifier.bibliographicCitationORAL ONCOLOGY, Vol.42(8) : 825-830, 2006-
dc.identifier.rimsid57360-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers

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