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Recombinant Allergens for Diagnosis and Immunotherapy of Allergic Disorders, with Emphasis on Cockroach Allergy

Authors
 Kyoung Y. Jeong  ;  Chein-Soo Hong  ;  Tai-Soon Yong 
Citation
 CURRENT PROTEIN & PEPTIDE SCIENCE, Vol.7(1) : 57-71, 2006 
Journal Title
CURRENT PROTEIN & PEPTIDE SCIENCE
ISSN
 1389-2037 
Issue Date
2006
MeSH
Allergens/immunology ; Allergens/therapeutic use* ; Animals ; Asthma/etiology ; Cockroaches/classification ; Cockroaches/immunology* ; Humans ; Hypersensitivity/diagnosis* ; Hypersensitivity/immunology ; Hypersensitivity/therapy* ; Models, Immunological ; Recombinant Proteins
Keywords
Allergen ; asthma ; cockroach ; immunotherapy ; recombinant allergen
Abstract
The prevalence of allergic disorders has increased over the past few decades and the quality of life has been significantly influenced at least for the allergic subjects. Allergen avoidance is thought to be the best way of preventing clinical manifestation of the disease, however, it is not possible for some allergens, and other pharmacological and/or immunological treatment has to be made. Repetitive injection of sensitized allergens to the patients (immunotherapy) is the only known curative approach to the disease even though the exact mechanism is not clear to date. Crude extract of allergens has lots of shortcomings which might arouse unexpected results. Genetic engineering and recombinant allergens are thought to be one of the alternative ways to overcome these limitations. Genetic engineering could facilitate the investigation of immune responses of the subjects especially on B cell and T cell epitopes, and produce the therapeutic allergens which might minimize the possible side effects. Furthermore, conjugation of immuno-modulatory molecules such as CpGODN, cytokines, or toxins which could act specifically to the given allergens, and maleylation of the allergens could maximize the prophylactic or therapeutic effect. Immunotherapies for the pollen allergy and insect sting allergy have been thought to be successful. House dust mite allergy and cockroach allergy have been reported less beneficial by immunotherapeutic approaches. Cockroaches are one of the most important causes of asthma, and severe complications are often reported in the children in city dwellers with lowincomes. The studies of the biological functions of cockroach allergens and the use of recombinant allergens should allow understanding of mechanisms of cockroach-elicited allergic disorders and development of allergen-specific and sensitive diagnostics and tailored therapeutic approaches in the future.
Full Text
http://www.eurekaselect.com/55404/article
DOI
10.2174/138920306775474112
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Tropica Medicine (열대의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Yong, Tai Soon(용태순) ORCID logo https://orcid.org/0000-0002-3445-0769
Jeong, Kyoung Yong(정경용) ORCID logo https://orcid.org/0000-0001-9887-1426
Hong, Chein Soo(홍천수)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109316
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