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Rosiglitazone relieves acute ethanol-induced hangover in Sprague-Dawley rats

Authors
 TAE WOO JUNG  ;  JI YOUNG LEE  ;  WAN SUB SHIM  ;  EUN SEOK KANG  ;  SOO KYUNG KIM  ;  CHUL WOO AHN  ;  HYUN CHUL LEE  ;  BONG SOO CHA 
Citation
 ALCOHOL AND ALCOHOLISM, Vol.41(3) : 231-235, 2006 
Journal Title
 ALCOHOL AND ALCOHOLISM 
ISSN
 0735-0414 
Issue Date
2006
MeSH
Animals ; Blotting, Western ; Central Nervous System Depressants/adverse effects* ; Central Nervous System Depressants/blood ; Cyanamide/pharmacology ; Ethanol/adverse effects* ; Ethanol/blood ; Hypoglycemic Agents/pharmacology* ; Immunoblotting ; Interpersonal Relations ; Male ; Mitochondria, Liver/drug effects ; Mitochondria, Liver/enzymology ; Rats ; Rats, Sprague-Dawley ; Reverse Transcriptase Polymerase Chain Reaction ; Rosiglitazone ; Social Behavior ; Thiazolidinediones/pharmacology* ; Up-Regulation/drug effects
Keywords
ethanol ; rosiglitazone ; acetaldehyde ; western blotting ; mitochondria ; cyanamide ; rats, sprague-dawley ; rats ; hangover from alcohol ; social interaction
Abstract
Aims: To assess the efficacy of rosiglitazone in blocking ethanol-induced hangover in rats. Methods: Rats injected with ethanol (4 g/kg body weight) were subjected to social interaction tests. Levels of aldehyde dehydrogenase 2 (ALD2), involved in an anti-hangover mechanism, were measured by semi-quantitative RT–PCR and western blot analysis. Results: Rosiglitazone caused an upregulation of mitochondrial ALD2, thus significantly detoxifying acetaldehyde. Conclusions: Rosiglitazone alleviated the symptoms of ethanol-induced hangover by inducing ALD2 expression; this result was reconfirmed by eliminating the effect of rosiglitazone by injecting cyanamide, an ALD2 inhibitor.
Files in This Item:
T200600419.pdf Download
DOI
10.1093/alcalc/agl013
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Hyun Chul(이현철)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109270
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