Cited 11 times in
Rosiglitazone relieves acute ethanol-induced hangover in Sprague-Dawley rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강은석 | - |
dc.contributor.author | 안철우 | - |
dc.contributor.author | 이현철 | - |
dc.contributor.author | 차봉수 | - |
dc.date.accessioned | 2015-06-10T12:08:43Z | - |
dc.date.available | 2015-06-10T12:08:43Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0735-0414 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109270 | - |
dc.description.abstract | Aims: To assess the efficacy of rosiglitazone in blocking ethanol-induced hangover in rats. Methods: Rats injected with ethanol (4 g/kg body weight) were subjected to social interaction tests. Levels of aldehyde dehydrogenase 2 (ALD2), involved in an anti-hangover mechanism, were measured by semi-quantitative RT–PCR and western blot analysis. Results: Rosiglitazone caused an upregulation of mitochondrial ALD2, thus significantly detoxifying acetaldehyde. Conclusions: Rosiglitazone alleviated the symptoms of ethanol-induced hangover by inducing ALD2 expression; this result was reconfirmed by eliminating the effect of rosiglitazone by injecting cyanamide, an ALD2 inhibitor. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 231~235 | - |
dc.relation.isPartOf | ALCOHOL AND ALCOHOLISM | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Blotting, Western | - |
dc.subject.MESH | Central Nervous System Depressants/adverse effects* | - |
dc.subject.MESH | Central Nervous System Depressants/blood | - |
dc.subject.MESH | Cyanamide/pharmacology | - |
dc.subject.MESH | Ethanol/adverse effects* | - |
dc.subject.MESH | Ethanol/blood | - |
dc.subject.MESH | Hypoglycemic Agents/pharmacology* | - |
dc.subject.MESH | Immunoblotting | - |
dc.subject.MESH | Interpersonal Relations | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mitochondria, Liver/drug effects | - |
dc.subject.MESH | Mitochondria, Liver/enzymology | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Rosiglitazone | - |
dc.subject.MESH | Social Behavior | - |
dc.subject.MESH | Thiazolidinediones/pharmacology* | - |
dc.subject.MESH | Up-Regulation/drug effects | - |
dc.title | Rosiglitazone relieves acute ethanol-induced hangover in Sprague-Dawley rats | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | TAE WOO JUNG | - |
dc.contributor.googleauthor | JI YOUNG LEE | - |
dc.contributor.googleauthor | WAN SUB SHIM | - |
dc.contributor.googleauthor | EUN SEOK KANG | - |
dc.contributor.googleauthor | SOO KYUNG KIM | - |
dc.contributor.googleauthor | CHUL WOO AHN | - |
dc.contributor.googleauthor | HYUN CHUL LEE | - |
dc.contributor.googleauthor | BONG SOO CHA | - |
dc.identifier.doi | 10.1093/alcalc/agl013 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00068 | - |
dc.contributor.localId | A02270 | - |
dc.contributor.localId | A03301 | - |
dc.contributor.localId | A03996 | - |
dc.relation.journalcode | J00059 | - |
dc.identifier.eissn | 1464-3502 | - |
dc.identifier.pmid | 16554376 | - |
dc.subject.keyword | ethanol | - |
dc.subject.keyword | rosiglitazone | - |
dc.subject.keyword | acetaldehyde | - |
dc.subject.keyword | western blotting | - |
dc.subject.keyword | mitochondria | - |
dc.subject.keyword | cyanamide | - |
dc.subject.keyword | rats, sprague-dawley | - |
dc.subject.keyword | rats | - |
dc.subject.keyword | hangover from alcohol | - |
dc.subject.keyword | social interaction | - |
dc.contributor.alternativeName | Kang, Eun Seok | - |
dc.contributor.alternativeName | Ahn, Chul Woo | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | Kang, Eun Seok | - |
dc.contributor.affiliatedAuthor | Ahn, Chul Woo | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Chul | - |
dc.contributor.affiliatedAuthor | Cha, Bong Soo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 41 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 231 | - |
dc.citation.endPage | 235 | - |
dc.identifier.bibliographicCitation | ALCOHOL AND ALCOHOLISM, Vol.41(3) : 231-235, 2006 | - |
dc.identifier.rimsid | 52238 | - |
dc.type.rims | ART | - |
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