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Cited 11 times in

Rosiglitazone relieves acute ethanol-induced hangover in Sprague-Dawley rats

DC Field Value Language
dc.contributor.author강은석-
dc.contributor.author안철우-
dc.contributor.author이현철-
dc.contributor.author차봉수-
dc.date.accessioned2015-06-10T12:08:43Z-
dc.date.available2015-06-10T12:08:43Z-
dc.date.issued2006-
dc.identifier.issn0735-0414-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/109270-
dc.description.abstractAims: To assess the efficacy of rosiglitazone in blocking ethanol-induced hangover in rats. Methods: Rats injected with ethanol (4 g/kg body weight) were subjected to social interaction tests. Levels of aldehyde dehydrogenase 2 (ALD2), involved in an anti-hangover mechanism, were measured by semi-quantitative RT–PCR and western blot analysis. Results: Rosiglitazone caused an upregulation of mitochondrial ALD2, thus significantly detoxifying acetaldehyde. Conclusions: Rosiglitazone alleviated the symptoms of ethanol-induced hangover by inducing ALD2 expression; this result was reconfirmed by eliminating the effect of rosiglitazone by injecting cyanamide, an ALD2 inhibitor.-
dc.description.statementOfResponsibilityopen-
dc.format.extent231~235-
dc.relation.isPartOfALCOHOL AND ALCOHOLISM-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHBlotting, Western-
dc.subject.MESHCentral Nervous System Depressants/adverse effects*-
dc.subject.MESHCentral Nervous System Depressants/blood-
dc.subject.MESHCyanamide/pharmacology-
dc.subject.MESHEthanol/adverse effects*-
dc.subject.MESHEthanol/blood-
dc.subject.MESHHypoglycemic Agents/pharmacology*-
dc.subject.MESHImmunoblotting-
dc.subject.MESHInterpersonal Relations-
dc.subject.MESHMale-
dc.subject.MESHMitochondria, Liver/drug effects-
dc.subject.MESHMitochondria, Liver/enzymology-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHReverse Transcriptase Polymerase Chain Reaction-
dc.subject.MESHRosiglitazone-
dc.subject.MESHSocial Behavior-
dc.subject.MESHThiazolidinediones/pharmacology*-
dc.subject.MESHUp-Regulation/drug effects-
dc.titleRosiglitazone relieves acute ethanol-induced hangover in Sprague-Dawley rats-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorTAE WOO JUNG-
dc.contributor.googleauthorJI YOUNG LEE-
dc.contributor.googleauthorWAN SUB SHIM-
dc.contributor.googleauthorEUN SEOK KANG-
dc.contributor.googleauthorSOO KYUNG KIM-
dc.contributor.googleauthorCHUL WOO AHN-
dc.contributor.googleauthorHYUN CHUL LEE-
dc.contributor.googleauthorBONG SOO CHA-
dc.identifier.doi10.1093/alcalc/agl013-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00068-
dc.contributor.localIdA02270-
dc.contributor.localIdA03301-
dc.contributor.localIdA03996-
dc.relation.journalcodeJ00059-
dc.identifier.eissn1464-3502-
dc.identifier.pmid16554376-
dc.subject.keywordethanol-
dc.subject.keywordrosiglitazone-
dc.subject.keywordacetaldehyde-
dc.subject.keywordwestern blotting-
dc.subject.keywordmitochondria-
dc.subject.keywordcyanamide-
dc.subject.keywordrats, sprague-dawley-
dc.subject.keywordrats-
dc.subject.keywordhangover from alcohol-
dc.subject.keywordsocial interaction-
dc.contributor.alternativeNameKang, Eun Seok-
dc.contributor.alternativeNameAhn, Chul Woo-
dc.contributor.alternativeNameLee, Hyun Chul-
dc.contributor.alternativeNameCha, Bong Soo-
dc.contributor.affiliatedAuthorKang, Eun Seok-
dc.contributor.affiliatedAuthorAhn, Chul Woo-
dc.contributor.affiliatedAuthorLee, Hyun Chul-
dc.contributor.affiliatedAuthorCha, Bong Soo-
dc.rights.accessRightsfree-
dc.citation.volume41-
dc.citation.number3-
dc.citation.startPage231-
dc.citation.endPage235-
dc.identifier.bibliographicCitationALCOHOL AND ALCOHOLISM, Vol.41(3) : 231-235, 2006-
dc.identifier.rimsid52238-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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