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Rosiglitazone protects human neuroblastoma SH-SY5Y cells against acetaldehyde-induced cytotoxicity

Authors
 Tae Woo Jung  ;  Ji Young Lee  ;  Wan Sub Shim  ;  Eun Seok Kang  ;  Soo Kyung Kim  ;  Chul Woo Ahn  ;  Hyun Chul Lee  ;  Bong Soo Cha 
Citation
 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.340(340) : 221-227, 2006 
Journal Title
 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 
ISSN
 0006-291X 
Issue Date
2006
MeSH
Acetaldehyde/toxicity* ; Apoptosis/drug effects* ; Cell Line, Tumor ; Cell Survival/drug effects* ; Dose-Response Relationship, Drug ; Drug Combinations ; Humans ; Neuroblastoma/pathology* ; Neuroblastoma/physiopathology* ; Neuroprotective Agents/administration & dosage ; Rosiglitazone ; Thiazolidinediones/administration & dosage*
Keywords
Acetaldehyde ; Parkinson’s disease ; PPAR-γ ; Rosiglitazone ; ROSApoptosis
Abstract
Acetaldehyde, an inhibitor of mitochondrial function, has been widely used as a neurotoxin because it elicits a severe Parkinson’s disease-like syndrome with elevation of the intracellular reactive oxygen species level and apoptosis. Rosiglitazone, a peroxisome proliferator-activated receptor-γ agonist, has been known to show various non-hypoglycemic effects, including anti-inflammatory, anti-atherogenic, and anti-apoptotic. In this study, we investigated the protective effects of rosiglitazone on acetaldehyde-induced apoptosis in human neuroblastoma SH-SY5Y cells and attempted to examine its mechanism. Acetaldehyde-induced apoptosis was moderately reversed by rosiglitazone treatment. Our results suggest that the protective effects of rosiglitazone on acetaldehyde-induced apoptosis may be ascribed to ability to induce the expression of anti-oxidant enzymes and to regulate Bcl-2 and Bax expression. These data indicate that rosiglitazone may provide a useful therapeutic strategy for the prevention of progressive neurodegenerative disease such as Parkinson’s disease.
Full Text
http://www.sciencedirect.com/science/article/pii/S0006291X05026987
DOI
10.1016/j.bbrc.2005.11.177
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Hyun Chul(이현철)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109207
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