Cited 42 times in
Rosiglitazone protects human neuroblastoma SH-SY5Y cells against acetaldehyde-induced cytotoxicity
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강은석 | - |
dc.contributor.author | 안철우 | - |
dc.contributor.author | 이현철 | - |
dc.contributor.author | 차봉수 | - |
dc.date.accessioned | 2015-06-10T12:06:36Z | - |
dc.date.available | 2015-06-10T12:06:36Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109207 | - |
dc.description.abstract | Acetaldehyde, an inhibitor of mitochondrial function, has been widely used as a neurotoxin because it elicits a severe Parkinson’s disease-like syndrome with elevation of the intracellular reactive oxygen species level and apoptosis. Rosiglitazone, a peroxisome proliferator-activated receptor-γ agonist, has been known to show various non-hypoglycemic effects, including anti-inflammatory, anti-atherogenic, and anti-apoptotic. In this study, we investigated the protective effects of rosiglitazone on acetaldehyde-induced apoptosis in human neuroblastoma SH-SY5Y cells and attempted to examine its mechanism. Acetaldehyde-induced apoptosis was moderately reversed by rosiglitazone treatment. Our results suggest that the protective effects of rosiglitazone on acetaldehyde-induced apoptosis may be ascribed to ability to induce the expression of anti-oxidant enzymes and to regulate Bcl-2 and Bax expression. These data indicate that rosiglitazone may provide a useful therapeutic strategy for the prevention of progressive neurodegenerative disease such as Parkinson’s disease. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 221~227 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acetaldehyde/toxicity* | - |
dc.subject.MESH | Apoptosis/drug effects* | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Survival/drug effects* | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Drug Combinations | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Neuroblastoma/pathology* | - |
dc.subject.MESH | Neuroblastoma/physiopathology* | - |
dc.subject.MESH | Neuroprotective Agents/administration & dosage | - |
dc.subject.MESH | Rosiglitazone | - |
dc.subject.MESH | Thiazolidinediones/administration & dosage* | - |
dc.title | Rosiglitazone protects human neuroblastoma SH-SY5Y cells against acetaldehyde-induced cytotoxicity | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Tae Woo Jung | - |
dc.contributor.googleauthor | Ji Young Lee | - |
dc.contributor.googleauthor | Wan Sub Shim | - |
dc.contributor.googleauthor | Eun Seok Kang | - |
dc.contributor.googleauthor | Soo Kyung Kim | - |
dc.contributor.googleauthor | Chul Woo Ahn | - |
dc.contributor.googleauthor | Hyun Chul Lee | - |
dc.contributor.googleauthor | Bong Soo Cha | - |
dc.identifier.doi | 10.1016/j.bbrc.2005.11.177 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00068 | - |
dc.contributor.localId | A02270 | - |
dc.contributor.localId | A03301 | - |
dc.contributor.localId | A03996 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.pmid | 16360119 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X05026987 | - |
dc.subject.keyword | Acetaldehyde | - |
dc.subject.keyword | Parkinson’s disease | - |
dc.subject.keyword | PPAR-γ | - |
dc.subject.keyword | Rosiglitazone | - |
dc.subject.keyword | ROSApoptosis | - |
dc.contributor.alternativeName | Kang, Eun Seok | - |
dc.contributor.alternativeName | Ahn, Chul Woo | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | Kang, Eun Seok | - |
dc.contributor.affiliatedAuthor | Ahn, Chul Woo | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Chul | - |
dc.contributor.affiliatedAuthor | Cha, Bong Soo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 340 | - |
dc.citation.number | 340 | - |
dc.citation.startPage | 221 | - |
dc.citation.endPage | 227 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.340(340) : 221-227, 2006 | - |
dc.identifier.rimsid | 55757 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.