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청소년 고혈압 관련 유전자의 연관성 분석 : Kangwha Study

Other Titles
 Association Analysis of the Essential Hypertension Susceptibility Genes in Adolescents : Kangwha Study 
 서일  ;  남정모  ;  김성주  ;  신동직  ;  허남욱  ;  강대룡 
 Journal of Preventive Medicine and Public Health, Vol.39(2) : 177-183, 2006 
Journal Title
 Journal of Preventive Medicine and Public Health 
Issue Date
Adolescent ; Genetic Markers ; Genetic Predisposition to Disease* ; Humans ; Hypertension/genetics* ; Korea ; Prospective Studies
Association analysis ; Hypertension ; Casecontrol study ; TDT ; Kangwha study
Objectives : In this study we examined the association between the genetic markers ACE (A-240T, C-93T, I/D, A2350G), AGT (M235T), AT1R (A1166C), CYP11B2 (T344C, V386A), REN (G2646A), ADRB2 (G46A, C79G, T47C, T1641), GNB3 (C825T) and ADD1 (G460W) and the presence of essential hypertension in adolescents. Methods : The Kangwha Study is an 18-year prospective study that is aimed at elucidating the determinants of the blood pressure level from childhood to early adulthood. For this study, we constructed a case-control dataset of size of 277 and 40 family trios data from the Kangwha Study. For this purpose, we perform a single locus-based case-control association study and a single locus-based TDT (transmission/disequilibrium test) study. Results : In the case-control study, the single locus-based association study indicated that the ADD1 (G460W) (p=0.0403), AGT (M235T) (p=0.0002), and REN (G2646A) (p=0.0101) markers were significantly associated with the risk of hypertension. These results were not confirmed on the TDT study. This study showed that genetic polymorphisms of the ADD1, AGT and REN genes might be related to the hypertension in Korean adolescents. Conclusions : This study provided useful information on genetics markers related to blood pressure. Further study will be needed to confirm the effect of the alpha adducin gene, the angiotensinogen gene and the renin gene on essential hypertension.
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1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Research Center for Human Natural Defense System (생체방어연구센터) > 1. Journal Papers
Yonsei Authors
Nam, Jung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Suh, Il(서일) ORCID logo https://orcid.org/0000-0002-9689-7849
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