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Botulinum Toxin Type A for Poststroke Cricopharyngeal Muscle Dysfunction

Authors
 Deog Young Kim  ;  Chang-il Park  ;  Suk Hoon Ohn  ;  Ja Young Moon  ;  Won Hyuk Chang  ;  Seung-woo Park 
Citation
 ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION, Vol.87(10) : 1346-1351, 2006 
Journal Title
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
ISSN
 0003-9993 
Issue Date
2006
MeSH
Aged ; Botulinum Toxins, Type A/therapeutic use* ; Esophageal Sphincter, Upper/physiopathology* ; Female ; Humans ; Male ; Middle Aged ; Muscular Diseases/drug therapy* ; Muscular Diseases/etiology ; Muscular Diseases/physiopathology ; Neuromuscular Agents/therapeutic use* ; Stroke/complications*
Keywords
Botulinum toxin type A ; Dysphagia ; Pharyngeal muscles ; Rehabilitation ; Stroke
Abstract
OBJECTIVE: To evaluate the therapeutic effectiveness of botulinum toxin type A (BTX-A) in poststroke patients with cricopharyngeal muscle dysfunction.
DESIGN: Before-after trial.
SETTING: University hospital.
PARTICIPANTS: Eight poststroke patients.
INTERVENTION: BTX-A injection into the cricopharyngeal muscle under endoscope guidance for poststroke cricopharyngeal muscle dysfunction.
MAIN OUTCOME MEASURES: Clinical symptom score, disability rating scale for swallowing impairment, videofluoroscopic swallowing study, and upper esophageal sphincter (UES) manometry.
RESULTS: Clinical symptom score, disability rating scale for swallowing impairment, residue in piriform sinus, and UES pressure were all significantly improved at 2 weeks after BTX-A injection compared with evaluations before injection (P<.05). The effects on the clinical symptom score and disability rating scale for swallowing impairment continued to be significantly improved to 12 weeks after injection (P<.05). However, the residue in piriform sinus and the UES pressure at 12 weeks postinjection were reduced compared with before-injection evaluations; these results were not significant. The pharyngeal transit time was not changed after injection. There were no side effects observed in the patients studied.
CONCLUSIONS: The results of the present study suggest that BTX-A injection may be an effective and safe treatment in patients with poststroke cricopharyngeal muscle dysfunction.
Full Text
http://www.sciencedirect.com/science/article/pii/S0003999306007246
DOI
10.1016/j.apmr.2006.06.018
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Deog Young(김덕용) ORCID logo https://orcid.org/0000-0001-7622-6311
Park, Seung Woo(박승우) ORCID logo https://orcid.org/0000-0001-8230-964X
Park, Chang Il(박창일)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109184
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