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Bilateral Anterior Cingulotomy for Refractory Obsessive-Compulsive Disorder: Long-Term Follow-Up Results

Authors
 Jung H.H.  ;  Kim C.-H.  ;  Chang J.H.  ;  Park Y.G.  ;  Chung S.S.  ;  Chang J.W. 
Citation
 STEREOTACTIC AND FUNCTIONAL NEUROSURGERY, Vol.84(4) : 184-189, 2006 
Journal Title
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
ISSN
 1011-6125 
Issue Date
2006
MeSH
Adult ; Anxiety Disorders/surgery ; Cognition ; Depressive Disorder/surgery ; Female ; Follow-Up Studies ; Functional Laterality ; Gyrus Cinguli/surgery* ; Humans ; Male ; Memory ; Middle Aged ; Neurosurgical Procedures/methods* ; Obsessive-Compulsive Disorder/surgery* ; Stereotaxic Techniques ; Treatment Outcome
Keywords
Obsessive-compulsive disorder ; Anterior cingulotomy ; Psychosurgery
Abstract
OBJECTIVE: To investigate the long-term efficacy and adverse cognitive effects of stereotactic bilateral anterior cingulotomy as a treatment for refractory obsessive-compulsive disorder (OCD) patients.
MATERIALS AND METHODS: Seventeen patients suffering from refractory OCD underwent stereotactic bilateral anterior cingulotomies and were followed for 24 months. The Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), the Clinical Global Impression and other neuropsychological tests were used to assess the efficacy and cognitive changes of cingulotomy. The tests were taken before and 12 and 24 months after surgery.
RESULTS: The mean improvement rate of the Y-BOCS score achieved from the baseline was 48%. Eight patients out of 17 met the responder criteria. During the 24-month follow-up, there were no significant adverse effects observed after surgery.
CONCLUSIONS: Bilateral anterior cingulotomy was effective for the treatment of refractory OCD, and no other significant adverse cognitive effects on long-term follow-up were found.
Full Text
http://www.karger.com/Article/FullText/95031
DOI
10.1159/000095031
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chan Hyung(김찬형)
Park, Yong Gou(박용구)
Chang, Jong Hee(장종희) ORCID logo https://orcid.org/0000-0003-1509-9800
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
Chung, Sang Sup(정상섭)
Jung, Hyun Ho(정현호)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109136
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