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Tissue Engineering of Heart Valves In Vivo Using Bone Marrow-derived Cells

Authors
 Sang-Soo Kim  ;  Sang-Hyun Lim  ;  Yoo-Sun Hong  ;  Seung-Woo Cho  ;  Ju Hee Ryu  ;  Byung-Chul Chang  ;  Cha Yong Choi  ;  Byung-Soo Kim 
Citation
 ARTIFICIAL ORGANS, Vol.30(7) : 554-557, 2006 
Journal Title
 ARTIFICIAL ORGANS 
ISSN
 0160-564X 
Issue Date
2006
MeSH
Animals ; Bone Marrow Cells/cytology* ; Cell Differentiation* ; Dogs ; Heart Valves* ; Implants, Experimental ; Tissue Engineering/methods*
Abstract
In this study, we tissue-engineered heart valves in vivo using autologous bone marrow-derived cells (BMCs). Canine BMCs were differentiated into endothelial cell (EC)-like cells and myofibroblast (MF)-like cells. Decellularized porcine pulmonary valves were seeded with BMCs and implanted to abdominal aorta and pulmonary valve of bone marrow donor dogs. Histological examination of the explants identified the regeneration of valvular structures expressing CD31 and smooth muscle α-actin, indicating the presence of EC-like and MF-like cells in the grafts at 3 and 1 week, respectively, after implantation. Fluorescent microscopic examinations identified the presence of fluorescently labeled cells in the explants, indicating that the implanted BMCs survived and participated in the heart valve reconstitution. This study reports, for the first time, on tissue engineering of heart valve in vivo using BMCs.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1525-1594.2006.00258.x/abstract
DOI
10.1111/j.1525-1594.2006.00258.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Chang, Byung Chul(장병철)
Hong, You Sun(홍유선)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109087
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