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Does the tibial and sural nerve transection model represent sympathetically independent pain?

 Dong Woo Han  ;  Tae Dong Kweon  ;  Ki Jun Kim  ;  Jong Seok Lee  ;  Chul Ho Chang  ;  Youn-woo Lee 
 YONSEI MEDICAL JOURNAL, Vol.47(6) : 847-851, 2006 
Journal Title
Issue Date
Animals ; Male ; Models, Animal* ; Neuralgia/classification* ; Neuralgia/diagnosis ; Rats ; Rats, Sprague-Dawley ; Sural Nerve/injuries* ; Sympathectomy ; Tibial Nerve/injuries* ; Tibial Neuropathy/classification* ; Tibial Neuropathy/physiopathology
Neuropathic pain ; sympathetically independent pain ; sympathetically maintained pain ; sympathectomy ; tibial nerve ; sural nerve ; transection
Neuropathic pain can be divided into sympathetically maintained pain (SMP) and sympathetically independent pain (SIP). Rats with tibial and sural nerve transection (TST) produce neuropathic pain behaviors, including spontaneous pain, tactile allodynia, and cold allodynia. The present study was undertaken to examine whether rats with TST would represent SMP- or SIP-dominant neuropathic pain by lumbar surgical sympathectomy. The TST model was generated by transecting the tibial and sural nerves, leaving the common peroneal nerve intact. Animals were divided into the sympathectomy group and the sham group. For the sympathectomy group, the sympathetic chain was removed bilaterally from L2 to L6 one week after nerve transection. The success of the sympathectomy was verified by measuring skin temperature on the hind paw and by infra red thermography. Tactile allodynia was assessed using von Frey filaments, and cold allodynia was assessed using acetone drops. A majority of the rats exhibited withdrawal behaviors in response to tactile and cold stimulations after nerve stimulation. Neither tactile allodynia nor cold allodynia improved after successful sympathectomy, and there were no differences in the threshold of tactile and cold allodynia between the sympathectomy and sham groups. Tactile allodynia and cold allodynia in the neuropathic pain model of TST are not dependent on the sympathetic nervous system, and this model can be used to investigate SIP syndromes.
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1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kweon, Tae Dong(권태동) ORCID logo https://orcid.org/0000-0002-5451-1856
Kim, Ki Jun(김기준) ORCID logo https://orcid.org/0000-0003-1950-7998
Lee, Youn Woo(이윤우)
Lee, Jong Seok(이종석) ORCID logo https://orcid.org/0000-0002-7945-2530
Chang, Chul Ho(장철호) ORCID logo https://orcid.org/0000-0001-5647-8298
Han, Dong Woo(한동우) ORCID logo https://orcid.org/0000-0002-8757-663X
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