0 344

Cited 13 times in

Induction of cell apoptosis in non-small cell lung cancer cells by cyclin A1 small interfering RNA

Authors
 Nam Hoon Cho  ;  Yoon Pyo Choi  ;  Dong Suk Moon  ;  Haeryoung Kim  ;  Suki Kang  ;  Owen Ding  ;  Sun Young Rha  ;  Yeon Ju Yang  ;  Sang Ho Cho 
Citation
 CANCER SCIENCE, Vol.97(10) : 1082-1092, 2006 
Journal Title
 CANCER SCIENCE 
ISSN
 1347-9032 
Issue Date
2006
MeSH
Apoptosis*/genetics ; Carcinoma, Non-Small-Cell Lung/genetics* ; Carcinoma, Non-Small-Cell Lung/metabolism ; Cell Cycle/genetics ; Cell Proliferation/drug effects ; Cyclin A/antagonists & inhibitors* ; Cyclin A/genetics ; Cyclin A/metabolism ; Cyclin A1 ; Gene Expression Profiling ; Humans ; Lung Neoplasms/genetics* ; Lung Neoplasms/metabolism ; RNA, Small Interfering/pharmacology* ; Tumor Cells, Cultured
Abstract
Cyclin A1 and cyclin B1 are overexpressed in various tumors but are present at low levels in normal tissues. Cyclin A1 is restricted to germ cells undergoing meiosis. In order to explore the possibility of using cyclin A1 and cyclin B1 as anticancer targets, we knocked them down in two lung cancer cell lines, H157 and H596, using siRNA. As with cyclin A1 siRNA in lung cancer cell lines, cyclin B1, Cdc2 and CDK2 were all significantly downregulated. The S phase fraction increased significantly, and they eventually underwent apoptosis by way of downregulated intrinsic apoptotic pathways and modulators with upregulated extrinsic apoptotic pathways. Our study suggests that cyclin A1 might be a promising anticancer target specific to lung cancer
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1349-7006.2006.00292.x/abstract
DOI
10.1111/j.1349-7006.2006.00292.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kang, Suki(강숙희) ORCID logo https://orcid.org/0000-0002-9957-3479
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Cho, Nam Hoon(조남훈) ORCID logo https://orcid.org/0000-0002-0045-6441
Cho, Sang Ho(조상호)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109038
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links