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Correlations of oral tongue cancer invasion with matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) expression

 Se-Heon Kim  ;  Nam Hoon Cho  ;  Kyubo Kim  ;  Jin Seok Lee  ;  Bon Seok Koo  ;  Jeong Hong Kim  ;  Jung Hyun Chang  ;  Eun Chang Choi 
 JOURNAL OF SURGICAL ONCOLOGY, Vol.93(4) : 330-337, 2006 
Journal Title
Issue Date
Adult ; Aged ; Biomarkers, Tumor/metabolism ; Female ; Humans ; Immunohistochemistry ; Lymph Nodes/pathology ; Lymphatic Metastasis ; Male ; Matrix Metalloproteinase 2/metabolism ; Matrix Metalloproteinase 9/metabolism ; Matrix Metalloproteinases/metabolism* ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Neovascularization, Pathologic/pathology ; Platelet Endothelial Cell Adhesion Molecule-1/metabolism ; Prognosis ; Survival Rate ; Tongue Neoplasms/blood supply ; Tongue Neoplasms/metabolism* ; Tongue Neoplasms/mortality ; Tongue Neoplasms/pathology* ; Vascular Endothelial Growth Factor A/metabolism*
tongue cancer ; tumor depth ; VEGF ; MMPs
BACKGROUND AND OBJECTIVES: In oral tongue cancer, the degree of tumor invasion has a significant effect on the prognosis. We hypothesized that the destruction of extracellular matrix and neovascularization are related to tumor infiltration mechanism. By studying the tissues of early stage oral tongue cancer patients, we are intending to clarify the invasion-related factors. MATERIALS AND METHODS: To demonstrate the invasion process in early T-stage oral tongue cancer, the expressions of extracellular matrix destruction-related molecules (MMP-2, MMP-9) and neovascularization-related molecule (VEGF) were observed by immunohistochemical study. Also, staining of CD31 was done for quantification of neovascularization. We analyzed relationship between expression of each substances and tumor invasion depth, tumor free survival rates, and cervical lymph node metastasis rate. RESULTS: The expression rates of MMP-2, MMP-9, VEGF in 38 early oral cancer patients were 52.6%, 78.9%, and 52.6%, respectively. Significant correlation was found between the VEGF expression and microvessel density showed by CD31 immunohistochemical staining (P < 0.001). VEGF expressions were significantly related with tumor invasion depth (P = 0.002). The tumor-free survival rate of those patients with VEGF-positive tumors was significantly poorer than in those with VEGF-negative tumors (P = 0.019). CONCLUSIONS: These results indicate that VEGF is a useful marker for predicting the tumor invasion in patients with early tongue cancer.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Heon(김세헌)
Cho, Nam Hoon(조남훈) ORCID logo https://orcid.org/0000-0002-0045-6441
Choi, Eun Chang(최은창)
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