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Correlations of oral tongue cancer invasion with matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) expression

DC FieldValueLanguage
dc.contributor.author김세헌-
dc.contributor.author조남훈-
dc.contributor.author최은창-
dc.date.accessioned2015-06-10T12:00:56Z-
dc.date.available2015-06-10T12:00:56Z-
dc.date.issued2006-
dc.identifier.issn0022-4790-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/109035-
dc.description.abstractBACKGROUND AND OBJECTIVES: In oral tongue cancer, the degree of tumor invasion has a significant effect on the prognosis. We hypothesized that the destruction of extracellular matrix and neovascularization are related to tumor infiltration mechanism. By studying the tissues of early stage oral tongue cancer patients, we are intending to clarify the invasion-related factors. MATERIALS AND METHODS: To demonstrate the invasion process in early T-stage oral tongue cancer, the expressions of extracellular matrix destruction-related molecules (MMP-2, MMP-9) and neovascularization-related molecule (VEGF) were observed by immunohistochemical study. Also, staining of CD31 was done for quantification of neovascularization. We analyzed relationship between expression of each substances and tumor invasion depth, tumor free survival rates, and cervical lymph node metastasis rate. RESULTS: The expression rates of MMP-2, MMP-9, VEGF in 38 early oral cancer patients were 52.6%, 78.9%, and 52.6%, respectively. Significant correlation was found between the VEGF expression and microvessel density showed by CD31 immunohistochemical staining (P < 0.001). VEGF expressions were significantly related with tumor invasion depth (P = 0.002). The tumor-free survival rate of those patients with VEGF-positive tumors was significantly poorer than in those with VEGF-negative tumors (P = 0.019). CONCLUSIONS: These results indicate that VEGF is a useful marker for predicting the tumor invasion in patients with early tongue cancer.-
dc.description.statementOfResponsibilityopen-
dc.format.extent330~337-
dc.relation.isPartOfJOURNAL OF SURGICAL ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBiomarkers, Tumor/metabolism-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHLymph Nodes/pathology-
dc.subject.MESHLymphatic Metastasis-
dc.subject.MESHMale-
dc.subject.MESHMatrix Metalloproteinase 2/metabolism-
dc.subject.MESHMatrix Metalloproteinase 9/metabolism-
dc.subject.MESHMatrix Metalloproteinases/metabolism*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Invasiveness-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHNeovascularization, Pathologic/pathology-
dc.subject.MESHPlatelet Endothelial Cell Adhesion Molecule-1/metabolism-
dc.subject.MESHPrognosis-
dc.subject.MESHSurvival Rate-
dc.subject.MESHTongue Neoplasms/blood supply-
dc.subject.MESHTongue Neoplasms/metabolism*-
dc.subject.MESHTongue Neoplasms/mortality-
dc.subject.MESHTongue Neoplasms/pathology*-
dc.subject.MESHVascular Endothelial Growth Factor A/metabolism*-
dc.titleCorrelations of oral tongue cancer invasion with matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) expression-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorSe-Heon Kim-
dc.contributor.googleauthorNam Hoon Cho-
dc.contributor.googleauthorKyubo Kim-
dc.contributor.googleauthorJin Seok Lee-
dc.contributor.googleauthorBon Seok Koo-
dc.contributor.googleauthorJeong Hong Kim-
dc.contributor.googleauthorJung Hyun Chang-
dc.contributor.googleauthorEun Chang Choi-
dc.identifier.doi10.1002/jso.20461-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00605-
dc.contributor.localIdA03812-
dc.contributor.localIdA04161-
dc.relation.journalcodeJ01762-
dc.identifier.eissn1096-9098-
dc.identifier.pmid16496371-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/jso.20461/abstract-
dc.subject.keywordtongue cancer-
dc.subject.keywordtumor depth-
dc.subject.keywordVEGF-
dc.subject.keywordMMPs-
dc.contributor.alternativeNameKim, Se Heon-
dc.contributor.alternativeNameCho, Nam Hoon-
dc.contributor.alternativeNameChoi, Eun Chang-
dc.contributor.affiliatedAuthorKim, Se Heon-
dc.contributor.affiliatedAuthorCho, Nam Hoon-
dc.contributor.affiliatedAuthorChoi, Eun Chang-
dc.rights.accessRightsnot free-
dc.citation.volume93-
dc.citation.number4-
dc.citation.startPage330-
dc.citation.endPage337-
dc.identifier.bibliographicCitationJOURNAL OF SURGICAL ONCOLOGY, Vol.93(4) : 330-337, 2006-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers

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