1 506

Cited 23 times in

Roles of sex steroid receptors and cell cycle regulation in pathogenesis of pelvic organ prolapse

Authors
 Da Jung Chung  ;  Sang Wook Bai 
Citation
 CURRENT OPINION IN OBSTETRICS & GYNECOLOGY, Vol.18(5) : 551-554, 2006 
Journal Title
CURRENT OPINION IN OBSTETRICS & GYNECOLOGY
ISSN
 1040-872X 
Issue Date
2006
MeSH
Apoptosis/physiology ; Cell Division/physiology ; Estrogen Receptor alpha/metabolism ; Estrogen Receptor beta/metabolism ; Female ; Humans ; Ovary/metabolism* ; Receptors, Steroid/metabolism* ; Uterine Prolapse/metabolism*
Keywords
cell proliferation and apoptosis, pathogenesis of POP, sex steroid receptors, sex steroids
Abstract
PURPOSE OF REVIEW: The cause of pelvic organ prolapse is multifactorial and many inciting, promoting and decompensating factors play a role in developing pelvic organ prolapse. Various clinical parameters have been studied quite extensively, but estrogen and collagen metabolism and cell proliferation and apoptosis have not been widely evaluated. This review focuses on assessing the roles of estrogen and its receptor, relationship with collagen metabolism and cell proliferation and cell apoptosis in development and progression of pelvic organ prolapse.
RECENT FINDINGS: Differential expressions of sex steroid receptors in various suspensory ligaments of prolapsed uteri have been studied. How different subtypes of estrogen receptor play a role in inducing and aggravating pelvic organ prolapse has yet to be defined. The role of estrogen in collagen metabolism and cell proliferation related to development of pelvic organ prolapse is still under study. Studies on the proliferation of fibroblasts in ligaments of pelvic organ prolapse have yielded conflicting results.
SUMMARY: There is still a need for additional research on precise roles of sex steroids, their receptors and cell cycle regulatory proteins and cell proliferation in pathogenesis of pelvic organ prolapse. Some of them could be the cause of pelvic organ prolapse and some of them the direct result of tissue trauma in pelvic organ prolapse.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001703-200610000-00013&LSLINK=80&D=ovft
DOI
10.1097/01.gco.0000242959.63362.1e
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Bai, Sang Wook(배상욱) ORCID logo https://orcid.org/0000-0001-7724-7552
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109027
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links